INT186921

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.85
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB1)
Anatomy Link Frequency
A549 3
epithelial cells 1
respiratory 1
DEFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 32 98.92 Very High Very High Very High
Inflammatory response 16 88.40 High High
headache 8 66.80 Quite High
fifth nerve 8 38.00 Quite Low
Pain 9 34.92 Quite Low
tolerance 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 72 99.82 Very High Very High Very High
INFLAMMATION 48 98.92 Very High Very High Very High
Injury 8 80.60 Quite High
Pharyngitis 8 67.48 Quite High
Headache 8 66.80 Quite High
Heart Rate Under Development 8 66.40 Quite High
Flushing 8 65.72 Quite High
Salivary Gland Disease 1 54.28 Quite High
Dental Caries 8 47.20 Quite Low
Dental Plaque 1 38.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the presence of a gene encoding a putative fucosidase enzyme (BDP_2152) indicates that B. dentium Bd1 can probably degrade fucose-containing glycans, such as those present in salivary mucins [68].
Protein_catabolism (degrade) of Bd1
1) Confidence 0.23 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2788695 Disease Relevance 0.05 Pain Relevance 0
The same experimental protocol was used to expose differentiated human bronchial cells to both ISO and BD photochemical degradation products.
Protein_catabolism (degradation) of BD
2) Confidence 0.02 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
In this study, we interfaced human lung epithelial cells with a smog chamber, allowing us to assess the toxicity of ISO, BD, and their photochemical degradation products in parallel.
Protein_catabolism (degradation) of BD in epithelial cells associated with toxicity
3) Confidence 0.02 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.62 Pain Relevance 0.09
In this study, we determined the relative toxicity and inflammatory gene expression induced by exposure of A549 cells to BD, ISO, and their photochemical degradation products in the presence of nitric oxide.
Protein_catabolism (degradation) of BD in A549 associated with toxicity and inflammation
4) Confidence 0.02 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1247611 Disease Relevance 0.26 Pain Relevance 0.08
One concern when analyzing the results of the photochemical degradation products for both ISO and BD was the production of O3 and its known toxic health effects.
Protein_catabolism (degradation) of BD
5) Confidence 0.02 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Triplicate sets of A549 cells were separately exposed to ISO plus nitrogen oxides (NOx), BD plus NOx, photochemical degradation products of ISO plus NOx, or photochemical degradation products of BD plus NOx for 5 hr.
Protein_catabolism (degradation) of BD in A549
6) Confidence 0.02 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.09 Pain Relevance 0.04
Although respiratory health effects induced by some of the photochemical degradation products of ISO and BD are known, the toxicity of the entire photochemical reaction product mixture as it would occur in the atmosphere is unknown.
Protein_catabolism (degradation) of BD in respiratory associated with toxicity
7) Confidence 0.02 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.68 Pain Relevance 0.11
In this study, A549 cells were exposed to ISO, BD, or their photochemical degradation products.
Protein_catabolism (degradation) of BD in A549
8) Confidence 0.02 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.14 Pain Relevance 0.03
Figures 2B and 3B show the photochemical degradation of the initial ISO or BD with the formation of the first-generation photochemical products from the time of injection through the end of the exposure period.
Protein_catabolism (degradation) of BD
9) Confidence 0.02 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0

General Comments

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