INT186923

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 2.69
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sputum 1
CEF 1
A549 1
IGKV2D-38 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 11 98.48 Very High Very High Very High
Inflammation 93 94.44 High High
cINOD 2 86.64 High High
aspirin 3 85.00 Quite High
metalloproteinase 20 84.56 Quite High
Inflammatory marker 7 54.40 Quite High
corticosteroid 15 47.92 Quite Low
Angina 17 40.72 Quite Low
Neurobehavioral 23 24.96 Low Low
psoriasis 2 16.40 Low Low
Disease Link Frequency Relevance Heat
Stress 64 100.00 Very High Very High Very High
Wound Healing 36 99.92 Very High Very High Very High
Asthma 27 98.28 Very High Very High Very High
INFLAMMATION 113 98.08 Very High Very High Very High
Pulmonary Disease 13 97.96 Very High Very High Very High
Pneumonia 7 95.96 Very High Very High Very High
Injury 44 89.16 High High
Aging 8 83.12 Quite High
Shock 4 77.08 Quite High
Lower Respiratory Tract Infection 2 71.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Associations increased with longer moving averages, with statistical significance being reached with the 1- to 6-day moving average for O3 and the 4- and 5-day moving average for SO2.
Positive_regulation (increased) of O3
1) Confidence 0.31 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.16 Pain Relevance 0.05
Previous studies have shown that A549 epithelial cells exposed to O3 concentrations less than those produced in these studies did increase IL-8 production (Jaspers et al. 1997), which would suggest that O3 is the major photochemical product causing the increase in IL-8 production.
Positive_regulation (increase) of O3 in A549
2) Confidence 0.30 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
The lengthening of stagnation events tends to increase summer O3 concentrations particularly during intense episodes near cities while a spatially mixed impact on annual PM2.5 levels is simulated.
Positive_regulation (increase) of O3
3) Confidence 0.16 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898046 Disease Relevance 0 Pain Relevance 0
VOC emissions are also important to O3 responses.
Positive_regulation (important) of O3
4) Confidence 0.12 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898046 Disease Relevance 0 Pain Relevance 0
Climate change modifies mean summer daily maximum 8-hour average O3 concentration levels by ±3% and mean annual PM2.5 concentrations by ?
Positive_regulation (average) of O3
5) Confidence 0.12 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898046 Disease Relevance 0 Pain Relevance 0
0.6%) decrease for an IQR increase of 19 ppb mean O3 in the previous 2 hr and a 3.4% (95% CI, ?
Positive_regulation (increase) of O3
6) Confidence 0.11 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854758 Disease Relevance 0 Pain Relevance 0
Climate change-related increased O3 health effects are less pronounced in the Great Lakes area and more pronounced for the southern states.


Positive_regulation (increased) of O3
7) Confidence 0.11 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898046 Disease Relevance 0 Pain Relevance 0
Hogrefe et al. [16] estimate that regional climate change alone will increase the summertime daily maximum 8-hour average O3 concentration over the eastern United States by 4 ppb in the 2050s.
Positive_regulation (increase) of O3
8) Confidence 0.11 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898046 Disease Relevance 0.06 Pain Relevance 0
20% squamous epithelial cells) as measured on their first baseline visit (sputum with no O3 exposure), and all were responsive to O3 (defined as ?
Positive_regulation (responsive) of O3 in sputum
9) Confidence 0.10 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.34 Pain Relevance 0.13
In epidemiologic investigations, exposure to increased levels of ambient air O3 has been associated with exacerbations of asthma, chronic obstructive pulmonary disease (COPD), and pneumonia, generally 24–48 hr after exposure occurs (Bernstein et al. 2004; Peden 2001).
Positive_regulation (increased) of O3 associated with asthma, pulmonary disease and pneumonia
10) Confidence 0.09 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.60 Pain Relevance 0.05
O3 exposure increased levels of Transforming Growth Factor (TGF-?)
Positive_regulation (increased) of O3
11) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910505 Disease Relevance 1.11 Pain Relevance 0.07
These differences in location between HSP27 and HSP70 might explain the different time course of induction of these stress proteins upon O3 exposure.
Positive_regulation (induction) of O3 associated with stress
12) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910505 Disease Relevance 0.42 Pain Relevance 0.15
O3 generated in situ by an O3 generator was delivered into the CEF and was maintained at a steady-state concentration of 40 ppb.
Positive_regulation (generated) of O3 in CEF
13) Confidence 0.01 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310916 Disease Relevance 0 Pain Relevance 0

General Comments

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