INT186924

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 2.64
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

translation factor activity, nucleic acid binding (EIF1) translation (EIF1) response to stress (EIF1)
cytoplasm (EIF1)
Anatomy Link Frequency
A549 6
dorsal thalamus 1
neurons 1
epithelial cells 1
respiratory 1
EIF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 36 99.72 Very High Very High Very High
Inflammation 96 98.84 Very High Very High Very High
Glutamate receptor 3 94.16 High High
antagonist 6 86.48 High High
Inflammatory response 48 84.08 Quite High
adenocard 21 83.32 Quite High
GABA receptor 3 71.48 Quite High
Glutamate 12 70.72 Quite High
headache 24 66.32 Quite High
Pain 24 60.80 Quite High
Disease Link Frequency Relevance Heat
Toxicity 216 99.08 Very High Very High Very High
INFLAMMATION 144 98.84 Very High Very High Very High
Cancer 168 95.32 Very High Very High Very High
Convulsion 12 91.00 High High
Injury 24 80.12 Quite High
Epilepsy 9 78.64 Quite High
Pharyngitis 24 67.00 Quite High
Headache 24 66.32 Quite High
Heart Rate Under Development 24 65.92 Quite High
Flushing 24 65.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many of the photochemical products for both ISO and BD have known health effects that have been studied in animals, humans, or both.
Gene_expression (products) of ISO
1) Confidence 0.08 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.18 Pain Relevance 0.13
Previous research has shown that many photochemical products of ISO and BD are known sensory irritants to either animals or humans.
Gene_expression (products) of ISO
2) Confidence 0.08 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Another reason for the observed differences in responses to ISO and BD photochemical products in A549 cells and differentiated human bronchial epithelial cells is that A549 cells are an immortalized cell line, whereas differentiated human bronchial epithelial cells are primary cells with a finite life span.
Gene_expression (products) of ISO in A549
3) Confidence 0.08 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
However, during the side-by-side experiment of photochemical products of ISO and BD, the average concentration of O3 inside the chambers was 120 ppb for ISO and 140 ppb for BD.
Gene_expression (products) of ISO
4) Confidence 0.08 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Although exposure to ISO and BD photochemical products generated significant levels of cytotoxicity and IL-8 expression in A549 cells, no significant effects were observed in differentiated human bronchial epithelial cells.
Gene_expression (products) of ISO in epithelial cells
5) Confidence 0.08 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
However, during the side-by-side experiment of photochemical products of ISO and BD, the average concentration of O3 inside the chambers was 120 ppb for ISO and 140 ppb for BD.
Gene_expression (products) of ISO
6) Confidence 0.08 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
The data presented here demonstrate that ISO and BD photochemical products increased LDH release as well as IL-8 expression compared with their clean air controls.
Gene_expression (products) of ISO
7) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Triplicate sets of A549 cells were separately exposed to ISO plus nitrogen oxides (NOx), BD plus NOx, photochemical degradation products of ISO plus NOx, or photochemical degradation products of BD plus NOx for 5 hr.
Gene_expression (products) of ISO in A549
8) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.08 Pain Relevance 0.04
Figure 5A shows that ISO photochemical products induced a greater change in IL-8 expression (IL-8 protein induced) compared with clean air control.
Gene_expression (products) of ISO
9) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Figure 4A shows that ISO photochemical products induce a significant increase in cytotoxicity compared with ISO plus NO alone.
Gene_expression (products) of ISO
10) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Triplicate sets of A549 cells were separately exposed to ISO plus nitrogen oxides (NOx), BD plus NOx, photochemical degradation products of ISO plus NOx, or photochemical degradation products of BD plus NOx for 5 hr.
Gene_expression (products) of ISO in A549
11) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.08 Pain Relevance 0.04
During the first experimental protocol comparing ISO or BD and their photochemical products, the initial injections of 200 ppbV ISO (99%; Sigma-Aldrich, St.
Gene_expression (products) of ISO
12) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
In this study, A549 cells were exposed to ISO, BD, or their photochemical degradation products.
Gene_expression (exposed) of ISO in A549
13) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.14 Pain Relevance 0.03
Data shown in Figures 2 and 3 and Table 1 indicate that, although photochemical reactions using ISO or BD as hydrocarbon precursors generate some of the same products (e.g., O3 or formaldehyde), several products are specific for either ISO or BD.
Gene_expression (specific) of ISO
14) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Gas chromatography and mass spectrometry analyses indicate the initial and major photochemical products produced during these experiments for BD are acrolein, acetaldehyde, and formaldehyde, and products for ISO are methacrolein, methyl vinyl ketone, and formaldehyde; both formed < 200 ppb of ozone.
Gene_expression (products) of ISO
15) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1247611 Disease Relevance 0.26 Pain Relevance 0.09
Triplicate sets of A549 cells were separately exposed to ISO plus nitrogen oxides (NOx), BD plus NOx, photochemical degradation products of ISO plus NOx, or photochemical degradation products of BD plus NOx for 5 hr.
Gene_expression (exposed) of ISO in A549
16) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.08 Pain Relevance 0.04
Some studies suggest that ISO oxidation can contribute significantly to the total O3 production rate during O3 episodes (Biesenthal et al. 1997).
Gene_expression (oxidation) of ISO
17) Confidence 0.07 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.21 Pain Relevance 0
One concern when analyzing the results of the photochemical degradation products for both ISO and BD was the production of O3 and its known toxic health effects.
Gene_expression (products) of ISO
18) Confidence 0.06 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Analyses by GC-FID and GC/MS of resulting photochemical ISO and BD atmospheric reaction products showed the formation of many known products.
Gene_expression (products) of ISO
19) Confidence 0.06 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Although respiratory health effects induced by some of the photochemical degradation products of ISO and BD are known, the toxicity of the entire photochemical reaction product mixture as it would occur in the atmosphere is unknown.
Gene_expression (products) of ISO in respiratory associated with toxicity
20) Confidence 0.06 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.68 Pain Relevance 0.11

General Comments

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