INT186941

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.70
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Nsdhl) endoplasmic reticulum (Nsdhl)
Anatomy Link Frequency
enamels 2
pituitary 1
brain 1
Nsdhl (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 140 99.96 Very High Very High Very High
midbrain 24 88.00 High High
Somatostatin 20 53.52 Quite High
imagery 5 50.00 Quite Low
Substantia nigra 12 38.60 Quite Low
gABA 64 37.68 Quite Low
GABAergic 8 15.88 Low Low
Locus ceruleus 40 5.00 Very Low Very Low Very Low
Pain 25 5.00 Very Low Very Low Very Low
Multiple sclerosis 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 69 99.08 Very High Very High Very High
Schizophrenia 880 98.44 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 40 93.16 High High
Suicidal Behaviour 8 92.80 High High
Autism 32 91.12 High High
Galactorrhea 16 88.76 High High
Targeted Disruption 25 74.88 Quite High
Body Weight 9 71.52 Quite High
Urological Neuroanatomy 16 71.32 Quite High
Congenital Anomalies 180 53.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we used this model to examine the ability of BPA—in comparison with known strong estrogens DES and 17?
Spec (examine) Localization (ability) of BPA
1) Confidence 0.46 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.26 Pain Relevance 0
Effect of perinatal exposure to BPA on the pubertal response to E2
Localization (exposure) of BPA
2) Confidence 0.37 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.46 Pain Relevance 0
BPA is a common ingredient of many plastic and resin products including food and drink containers, internal linings of food cans, and dental enamels.67 Also known as 2,2-bis(4-hydroxyphenyl) propane, BPA was invented in the 20th century68 and is manufactured by combining acetone and phenol.69 Emerging research indicates BPA is an estrogenic EDC that alters or interferes with normal endocrine development in various vertebrate and invertebrate species.70
Localization (invented) of BPA in enamels
3) Confidence 0.31 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.51 Pain Relevance 0
One study examined the effects of BPA exposure on LH and T when exposure occurred during the postnatal period in rats.67 BPA exposure suppressed serum LH and T and decreased LHbeta and ERbeta pituitary mRNA.
Localization (exposure) of BPA in pituitary
4) Confidence 0.31 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.65 Pain Relevance 0.05
BPA is a common ingredient of many plastic and resin products including food and drink containers, internal linings of food cans, and dental enamels.67 Also known as 2,2-bis(4-hydroxyphenyl) propane, BPA was invented in the 20th century68 and is manufactured by combining acetone and phenol.69 Emerging research indicates BPA is an estrogenic EDC that alters or interferes with normal endocrine development in various vertebrate and invertebrate species.70
Localization (invented) of BPA in enamels
5) Confidence 0.31 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.56 Pain Relevance 0
BPA rapidly releases DA from PC12 cells,176 and treatment of mouse astrocyte/neuronal cells with BPA enhances Ca2+ response to DA.102 In males exposed prenatally and neonatally to BPA, DA D1 receptor mRNA is upregulated in the whole brain.174
Localization (releases) of BPA in brain associated with dopamine
6) Confidence 0.29 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.26 Pain Relevance 0.69

General Comments

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