INT186957

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.71
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nsdhl, Tmed4) signal transduction (Tmed4) transport (Tmed4)
oxidoreductase activity (Nsdhl) signal transducer activity (Tmed4)
Anatomy Link Frequency
embryos 3
Nsdhl (Mus musculus)
Tmed4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 25 99.82 Very High Very High Very High
Potency 45 93.12 High High
Bioavailability 5 41.92 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 100 99.84 Very High Very High Very High
Sprains And Strains 30 65.96 Quite High
Congenital Anomalies 15 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Spontaneous Abortion 5 5.00 Very Low Very Low Very Low
Aneuploidy 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, our results show that in utero activation of ERs by BPA, at early time points after exposure, requires much lower doses than extrapolations from in vitro measurements would predict.
BPA Positive_regulation (activation) of ERs
1) Confidence 0.04 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.05 Pain Relevance 0.03
BPA activates ERs in transgenic embryos.
BPA Positive_regulation (activates) of ERs in embryos associated with targeted disruption
2) Confidence 0.04 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.10 Pain Relevance 0
In conclusion, we have shown that the mouse model presented here can be used to detect activation of ERs by maternally applied BPA and that other estrogens can be detected in living embryos in utero.
BPA Positive_regulation (activation) of ERs in embryos
3) Confidence 0.03 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.24 Pain Relevance 0
Therefore, at least at early time points, BPA is able to transactivate the embryonic ERs and resembles DES rather than EP in its kinetics of luciferase activation.


BPA Positive_regulation (transactivate) of ERs
4) Confidence 0.03 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.22 Pain Relevance 0.09
We show that, using this in vivo model in combination with the IVIS imaging system, activation of estrogen receptors (ERs) by maternally applied BPA and other estrogens can be detected in living embryos in utero.
BPA Positive_regulation (activation) of ERs in embryos associated with imagery
5) Confidence 0.03 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1247619 Disease Relevance 0.09 Pain Relevance 0.12

General Comments

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