INT186972

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Atxn1) DNA binding (Atxn1) cytoplasm (Atxn1)
RNA binding (Atxn1) nucleolus (Atxn1) nucleus (Atxn1)
Anatomy Link Frequency
stem cell 2
Atxn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 4 69.76 Quite High
alcohol 12 64.00 Quite High
Central nervous system 4 57.56 Quite High
cerebral cortex 8 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 38 87.68 High High
Alcohol Addiction 2 64.00 Quite High
Fetal Alcohol Syndrome 12 25.40 Quite Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Genomic Instability 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low
Chromosomal Instability 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While Sca-1 may well exhibit different developmental-stage associated kinetics in the neuroepithelium, ethanol-dependent depletion of Sca-1 in the neuroepithelium may similarly drive precursor maturation and prevent the renewal of a stem cell pool.
Negative_regulation (depletion) of Sca-1 in stem cell
1) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.06 Pain Relevance 0.10
In the context of the previously noted requirement for cell cycle induction as a component of stem cell to blast cell transformation [26], it is interesting to note that the suppression of the stem cell marker Sca-1 [70]) promotes myoblast proliferation.
Negative_regulation (suppression) of Sca-1 in stem cell
2) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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