INT186977

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.49
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) DNA binding (Tert) cytoplasm (Tert)
chromosome (Tert) nucleolus (Tert) nucleus (Tert)
Anatomy Link Frequency
neurons 1
Tert (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 8 51.08 Quite High
alcohol 24 50.64 Quite High
tolerance 4 15.12 Low Low
cerebral cortex 16 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 76 99.26 Very High Very High Very High
Chromosomal Instability 8 89.12 High High
Death 20 85.20 High High
Ataxia 4 67.28 Quite High
Genomic Instability 16 53.52 Quite High
Alcohol Addiction 4 51.08 Quite High
Aneuploidy 8 32.00 Quite Low
Fetal Alcohol Syndrome 24 23.44 Low Low
Neurodegenerative Disease 24 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Though activity is decreased following cellular differentiation, the catalytic component of telomerase (TERT) continues to be expressed widely in post-mitotic neurons where it appears to function as a neuroprotective factor [40,41,85].
Gene_expression (expressed) of TERT in neurons
1) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.43 Pain Relevance 0.05
In contrast, the suppression of TERT mRNA expression at high doses (620 mg/dl) is inconsistent with the observed increase in cell cycle progression at that dose.
Gene_expression (expression) of TERT mRNA
2) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.45 Pain Relevance 0
Interestingly, TERT physically associates with the anti-apoptotic kinase AKT [86], and a reduction in TERT expression levels has the potential to render dividing cortical precursors susceptible to future apoptotic stimuli, (for example, see [41,87,88]), even if ethanol itself does not induce apoptosis.
Gene_expression (expression) of TERT associated with apoptosis
3) Confidence 0.32 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.61 Pain Relevance 0
TERT and nestin mRNA levels were quantified by densitometric measurement, and were expressed as a ratio of cyclophilin-A mRNA expression (Molecular Analyst for Windows, BioRad).
Gene_expression (expressed) of TERT
4) Confidence 0.25 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0

General Comments

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