INT186981

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.73
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Atxn1) DNA binding (Atxn1) cytoplasm (Atxn1)
RNA binding (Atxn1) nucleolus (Atxn1) nucleus (Atxn1)
Anatomy Link Frequency
stem cell 5
lymphocyte 1
stem 1
Atxn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 29 79.04 Quite High
Central nervous system 14 74.00 Quite High
addiction 14 50.72 Quite High
alcohol 42 44.96 Quite Low
antagonist 39 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
gABA 22 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 134 94.72 High High
Neurodegenerative Disease 42 74.56 Quite High
Cancer 36 69.76 Quite High
Death 35 58.20 Quite High
Alcohol Addiction 7 44.96 Quite Low
Genomic Instability 28 42.96 Quite Low
Fetal Alcohol Syndrome 42 41.84 Quite Low
Stress 48 14.00 Low Low
Leukemia 1 10.72 Low Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, ethanol induced asymmetric division in progenitor cells and decreased the cell surface expression of a number of stem cell markers, i.e., c-kit/CD117, Sca-1 (Ly6A/E), CD133/prominin-1 and the ABCG2 transporter.
Gene_expression (expression) of Sca-1 in stem cell
1) Confidence 0.05 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.47 Pain Relevance 0.07
These data suggest that while ethanol may not decrease the overall size of the precursor pool (the combined stem and blast pool, indicated by constant nestin mRNA expression), it decreases the diversity of stem cells within this pool (indicated by decreased numbers of cells expressing Sca-1, c-kit, CD133 and ABCG2).


Gene_expression (expressing) of Sca-1 in stem
2) Confidence 0.05 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
However, contrary to our hypothesis, we observed a large and statistically significant decrease in the numbers of cells expressing Sca-1 (~23-fold), CD117/C-kit (~9-fold) and CD133/prominin-1 (~19-fold) on their cell surface, after treatment with ethanol at 120 mg/dl (p < 0.05, N = 9 samples per stem cell antigen group).
Gene_expression (expressing) of Sca-1 in stem cell
3) Confidence 0.05 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
In the initial set of experiments, we utilized flow-cytometry to examine the expression of three stem cell markers, Sca-1 (Ly6A/E), CD117/c-kit and CD133/prominin-1.
Spec (examine) Gene_expression (expression) of Sca-1 in stem cell
4) Confidence 0.05 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Ethanol significantly reduced the numbers of cells expressing the stem cell markers CD117, CD133, Sca-1 and ABCG2, without decreasing nestin expression.
Gene_expression (expressing) of Sca-1 in stem cell
5) Confidence 0.04 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1249578 Disease Relevance 0.16 Pain Relevance 0.04
Sca-1 expression is suppressed in hematopoietic stem cells, during the process of lymphocyte differentiation [75].
Gene_expression (expression) of Sca-1 in lymphocyte
6) Confidence 0.04 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0.03
In contrast, ethanol significantly decreased the numbers of cells that expressed cell-surface Sca-1, c-kit, CD133 and ABCG2.
Gene_expression (expressed) of Sca-1
7) Confidence 0.04 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.09 Pain Relevance 0.07
The SP cells include nestin-positive cells (656) and cells expressing stem cell antigen-1 (sca-1) and markers typical for stem cells in other tissues (Oct-4 and nanog) and early embryonic markers such as Lhx4 and molecules belonging to the Notch, Sonic hedgehog and Wnt signalling pathways (657).
Gene_expression (expressing) of sca-1 in stem cell
8) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0

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