INT186982

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Atxn1) DNA binding (Atxn1) cytoplasm (Atxn1)
RNA binding (Atxn1) nucleolus (Atxn1) nucleus (Atxn1)
Anatomy Link Frequency
lymphocyte 2
stem cell 2
Atxn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 8 76.88 Quite High
addiction 4 51.84 Quite High
alcohol 12 46.08 Quite Low
Central nervous system 4 10.92 Low Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 38 80.96 Quite High
Neurodegenerative Disease 12 74.56 Quite High
Cancer 4 70.84 Quite High
Death 10 59.28 Quite High
Alcohol Addiction 2 46.08 Quite Low
Fetal Alcohol Syndrome 12 5.00 Very Low Very Low Very Low
Genomic Instability 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low
Chromosomal Instability 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sca-1 expression is suppressed in hematopoietic stem cells, during the process of lymphocyte differentiation [75].
Negative_regulation (suppressed) of Gene_expression (expression) of Sca-1 in lymphocyte
1) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0.03
On the other hand, ethanol induced asymmetric division in progenitor cells and decreased the cell surface expression of a number of stem cell markers, i.e., c-kit/CD117, Sca-1 (Ly6A/E), CD133/prominin-1 and the ABCG2 transporter.
Negative_regulation (decreased) of Gene_expression (expression) of Sca-1 in stem cell
2) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.48 Pain Relevance 0.07

General Comments

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