INT186986

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) DNA binding (Tert) cytoplasm (Tert)
chromosome (Tert) nucleolus (Tert) nucleus (Tert)
Tert (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 6 30.76 Quite Low
alcohol 18 30.32 Quite Low
tolerance 3 14.24 Low Low
cerebral cortex 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 57 99.52 Very High Very High Very High
Chromosomal Instability 6 68.80 Quite High
Ataxia 3 66.40 Quite High
Death 15 64.88 Quite High
Genomic Instability 12 52.64 Quite High
Aneuploidy 6 31.12 Quite Low
Alcohol Addiction 3 30.76 Quite Low
Fetal Alcohol Syndrome 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 18 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, high levels of ethanol (620 mg/dl) produced a statistically significant decrease in TERT mRNA levels.
Negative_regulation (decrease) of TERT mRNA
1) Confidence 0.27 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Interestingly, TERT physically associates with the anti-apoptotic kinase AKT [86], and a reduction in TERT expression levels has the potential to render dividing cortical precursors susceptible to future apoptotic stimuli, (for example, see [41,87,88]), even if ethanol itself does not induce apoptosis.
Negative_regulation (reduction) of TERT associated with apoptosis
2) Confidence 0.24 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.61 Pain Relevance 0
Ethanol reduces telomerase reverse transcriptase (TERT) mRNA levels in neurosphere cultures
Negative_regulation (reduces) of TERT
3) Confidence 0.20 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0

General Comments

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