INT186988

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) DNA binding (Tert) cytoplasm (Tert)
chromosome (Tert) nucleolus (Tert) nucleus (Tert)
Tert (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 4 40.12 Quite Low
alcohol 12 39.68 Quite Low
tolerance 2 15.12 Low Low
cerebral cortex 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 38 99.52 Very High Very High Very High
Chromosomal Instability 4 78.16 Quite High
Death 10 74.24 Quite High
Ataxia 2 67.28 Quite High
Genomic Instability 8 53.52 Quite High
Alcohol Addiction 2 40.12 Quite Low
Aneuploidy 4 32.00 Quite Low
Fetal Alcohol Syndrome 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the suppression of TERT mRNA expression at high doses (620 mg/dl) is inconsistent with the observed increase in cell cycle progression at that dose.
Negative_regulation (suppression) of Gene_expression (expression) of TERT mRNA
1) Confidence 0.27 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.46 Pain Relevance 0
Interestingly, TERT physically associates with the anti-apoptotic kinase AKT [86], and a reduction in TERT expression levels has the potential to render dividing cortical precursors susceptible to future apoptotic stimuli, (for example, see [41,87,88]), even if ethanol itself does not induce apoptosis.
Negative_regulation (reduction) of Gene_expression (expression) of TERT associated with apoptosis
2) Confidence 0.24 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.61 Pain Relevance 0

General Comments

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