INT186995

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 2.31
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (RBFOX3) RNA binding (RBFOX3) nucleus (RBFOX3)
intracellular (RBFOX3) DNA binding (RBFOX3) cytoplasm (RBFOX3)
Anatomy Link Frequency
neuronal 8
grid 1
endothelial cell 1
astrocytes 1
nucleus 1
RBFOX3 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 10 99.92 Very High Very High Very High
cytokine 14 99.46 Very High Very High Very High
Substantia nigra 165 93.32 High High
adenocard 2 89.04 High High
Dopamine 68 83.56 Quite High
ischemia 50 73.60 Quite High
Inflammation 24 72.68 Quite High
tetrodotoxin 25 72.24 Quite High
Neuritis 2 69.92 Quite High
Nerve growth factor 4 63.68 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 67 90.72 High High
Toxicity 42 90.24 High High
Brain Injury 29 89.64 High High
Brain Hemorrhage 119 88.00 High High
Heat Stroke 18 86.84 High High
Hypoxia 16 82.40 Quite High
Apoptosis 59 77.36 Quite High
Injury 29 74.04 Quite High
INFLAMMATION 30 72.68 Quite High
Thrombophilia 3 71.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cells expressed the neuronal markers, NeuN and MAP-2, and the astrocytic marker, GFAP.
Gene_expression (expressed) of NeuN in neuronal
1) Confidence 0.30 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 1.20 Pain Relevance 0.13
Under in vitro treatment with neuronal conditioning medium, NGF and interferon-gamma, these cells differentiated into a neuronal-like lineage, expressing neuronal (NeuN, neuron specific enolase-NSE, neurofilaments, microtubulin associated protein-MAP-2) and glial cells (GFAP) markers [18].
Gene_expression (expressing) of NeuN in neuronal
2) Confidence 0.30 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
CB cells survive, and some express cell type┬ľ specific neuronal markers NeuN (2%) and MAP-2 (3%), astrocye marker GFAP (6%) and endothelial cell marker FVIII (8%).
Gene_expression (express) of NeuN in endothelial cell
3) Confidence 0.23 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0.23 Pain Relevance 0.09
The cells were first stained with the primary antibody Nestin (1:100), BT (1:100), TH (1:100), Neurofilament (1:100), NeuN (1:100), and GFAP (1:100).The primary antibody was detected using secondary goat anti-mouse Alexa 488 and Alexa 568 (Molecular Probes, USA).
Gene_expression (stained) of NeuN
4) Confidence 0.20 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0.07 Pain Relevance 0.03
Induced cells with Neuronal Progenitor Basal Medium (NPBM medium) or Neurobasal added with a mix cytokines, demonstrate an increased expression of Tyrosine Hydroxylase (TH), MAP-2, NF, NeuN, GABA, nestin and GFAP [14,16].
Gene_expression (expression) of NeuN in Neuronal associated with gaba and cytokine
5) Confidence 0.16 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.07 Pain Relevance 0.17
Parameters used for NeuN stereological counting were grid size, 480 ?
Gene_expression (counting) of NeuN in grid
6) Confidence 0.15 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0 Pain Relevance 0.19
Our experiments demonstrate that NI-hADSCs express increased immunoreactivities for neuronal markers Tuj1, MAP2, NFL, NFM, NFH, NSE, NeuN, GAP43, and SNAP25, as well as the increased mRNA expression of Tuj1, MAP2, NFL, NFM, NSE, GAP43, and SNAP25 compared to primary hADSCs (Figure 3), indicating that hADSCs differentiate into neural cells via bFGF and forskolin-mediated differentiation.
Gene_expression (express) of NeuN in neuronal
7) Confidence 0.14 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.04
In both cases (TH and NeuN cell number), the rats that received AAV1/2-A53T ?
Gene_expression (number) of NeuN
8) Confidence 0.13 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.23 Pain Relevance 0.27
NeuN cell counts were also significantly reduced in AAV1/2-A53T ?
Gene_expression (counts) of NeuN
9) Confidence 0.13 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.15 Pain Relevance 0.24
Undifferentiated ADSCs also express markers characteristic of neural cells such as NSE, vimentin, and NeuN [57].
Gene_expression (express) of NeuN in neural
10) Confidence 0.12 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.07
Louis, Mo, USA, 1 : 100), rat anti-neuronal nuclei (NeuN) monoclonal antibody (Chemicon, Temecula, CA, USA, 1 : 100), rat anti-glial fibrillary acidic protein (GFAP) monoclonal antibody (Boehringer, Mannheim, Germany, 1 : 200), rat anti-2', 3'-cyclic nucleotide 3'-phosphodiesterase monoclonal antibody (CNPase) (Chemicon, Temecula, CA, USA, 1: 100) for 16~18 h at 4?
Gene_expression (antibody) of NeuN in neuronal
11) Confidence 0.10 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998786 Disease Relevance 0 Pain Relevance 0
MSCs were negative for several neural proteins including the differentiating neuron marker Tuj-1, the mature neuron marker NeuN, GFAP typical of astrocytes, and the oligodendrocyte marker MBP.
Neg (negative) Gene_expression (negative) of NeuN in astrocytes
12) Confidence 0.10 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0 Pain Relevance 0.03
Conversely, expression of Tuj-1 and NeuN increased significantly after neurogenic stimulation in BDNF-transfected hUCB-MSCs.
Gene_expression (expression) of NeuN
13) Confidence 0.10 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0 Pain Relevance 0.03
Neurosphere cultures were assayed for the expression of the neuroepithelial marker Nestin, and neuronal marker NeuN (neuronal nuclear antigen), according to previously published protocols [54].
Gene_expression (expression) of NeuN in neuronal
14) Confidence 0.08 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
In contrast, differentiation, induced by removal of Epidermal Growth Factor and culturing neurosphere-derived cells on a laminin substrate, leads to clear nuclear expression of NeuN (Figure 1C) and suppression of nestin immunoreactivity (data not shown), suggesting that neurosphere-derived cells can be committed to a neuronal lineage.
Gene_expression (expression) of NeuN in neuronal
15) Confidence 0.07 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.21 Pain Relevance 0
In contrast, immunofluorescence for the neuronal nuclear antigen (NeuN) was expressed within the soma of a few progenitor cells at the periphery of the neurosphere, but did not co-localize to any nucleus (Figure 1B).
Gene_expression (expressed) of NeuN in nucleus
16) Confidence 0.06 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.15 Pain Relevance 0
III tubulin, NeuN (a neuronal marker), and GFAP expression in the adult cells but not in the eNPC.
Gene_expression (expression) of NeuN in neuronal
17) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2225502 Disease Relevance 0 Pain Relevance 0

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