INT186998

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 16.77
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT)
nucleus (KIT) cytoplasm (KIT)
Anatomy Link Frequency
stem cell 10
3G3 4
fibroblasts 2
epithelial cells 2
stem 2
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 16 80.20 Quite High
substance P 10 77.24 Quite High
nud 1 71.60 Quite High
palliative 7 67.68 Quite High
Pain 11 53.24 Quite High
cytokine 7 52.16 Quite High
headache 4 46.16 Quite Low
abdominal pain 4 23.12 Low Low
Neurotransmitter 8 21.60 Low Low
cva 4 7.52 Low Low
Disease Link Frequency Relevance Heat
Necrosis 12 99.36 Very High Very High Very High
Breast Cancer 47 98.72 Very High Very High Very High
Cancer 519 98.24 Very High Very High Very High
Hematologic Neoplasms 6 97.52 Very High Very High Very High
Stomach Cancer 255 97.44 Very High Very High Very High
Hyperplasia 4 97.36 Very High Very High Very High
Stress 1 96.50 Very High Very High Very High
Gastrointestinal Stromal Tumor 210 96.28 Very High Very High Very High
Head & Neck Cancer 23 95.20 Very High Very High Very High
Ovarian Cancer 194 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study, none of the studied 38 cases displayed a CD117 expression immunohistochemically.
Negative_regulation (displayed) of Gene_expression (expression) of CD117
1) Confidence 0.43 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.03 Pain Relevance 0
Interestingly, normal breast epithelial cells abundantly express c-kit, whereas a loss of c-kit expression has been reported in 80–90% of breast cancer cases [37].
Negative_regulation (loss) of Gene_expression (expression) of kit in epithelial cells associated with breast cancer
2) Confidence 0.43 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.78 Pain Relevance 0.03
Immunohistochemical analysis revealed expression of C-kit (strongly positive), moderately positive stain for SMA, while markers for focal S-100 and CD 34 were negative (Figure 5).
Negative_regulation (revealed) of Gene_expression (expression) of C-kit
3) Confidence 0.43 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2664807 Disease Relevance 1.32 Pain Relevance 0
Expression of CD117, c-kit and the stem cell factor (SCF) receptor
Negative_regulation (receptor) of Gene_expression (Expression) of kit in stem cell
4) Confidence 0.42 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.07 Pain Relevance 0
An additional agent is associated with the expression and inhibition of CD117 (c-kit), and has been effectively used in various neoplasms such as hematological malignancies and gastrointestinal stromal tumors (GIST).
Negative_regulation (inhibition) of Gene_expression (expression) of CD117 associated with cancer, hematologic neoplasms and gastrointestinal stromal tumor
5) Confidence 0.42 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.62 Pain Relevance 0.05
An additional agent is associated with the expression and inhibition of CD117 (c-kit), and has been effectively used in various neoplasms such as hematological malignancies and gastrointestinal stromal tumors (GIST).
Negative_regulation (inhibition) of Gene_expression (expression) of kit associated with cancer, hematologic neoplasms and gastrointestinal stromal tumor
6) Confidence 0.42 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.62 Pain Relevance 0.05
Expression of CD117, c-kit and the stem cell factor (SCF) receptor
Negative_regulation (receptor) of Gene_expression (Expression) of CD117 in stem cell
7) Confidence 0.42 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.07 Pain Relevance 0
A summary of the ongoing trials investigating the combination of PLD with other growth factor receptor inhibitors such as IMC-3G3, an inhibitor of PDGF-R (NCT00913835), panitumumab (an EGF-R blocker) (NCT00861120), and pazopanib (which interferes with VEGF-R1,2,3 kinase, PDGF-R and c-kit oncogene product) (NCT01035658) can be found at the www.clinicaltrials.gov.
Negative_regulation (inhibitors) of Gene_expression (product) of c-kit in 3G3
8) Confidence 0.41 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952486 Disease Relevance 0.26 Pain Relevance 0
A summary of the ongoing trials investigating the combination of PLD with other growth factor receptor inhibitors such as IMC-3G3, an inhibitor of PDGF-R (NCT00913835), panitumumab (an EGF-R blocker) (NCT00861120), and pazopanib (which interferes with VEGF-R1,2,3 kinase, PDGF-R and c-kit oncogene product) (NCT01035658) can be found at the www.clinicaltrials.gov.
Negative_regulation (inhibitor) of Gene_expression (product) of c-kit in 3G3
9) Confidence 0.41 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952486 Disease Relevance 0.26 Pain Relevance 0
The tumor invaded into the submucosa, showed no signs of necrosis and had positive expression of c-kit (figure 2), focally positive expression of SMA, and negative expression of CD34.
Negative_regulation (expression) of Gene_expression (expression) of c-kit associated with necrosis and cancer
10) Confidence 0.39 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2965163 Disease Relevance 0.94 Pain Relevance 0
Our findings of significant loss of c-Kit expression in Case 2 are consistent with other changes noted in this patient as well as with emerging reports in humans.
Negative_regulation (loss) of Gene_expression (expression) of c-Kit
11) Confidence 0.39 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.83 Pain Relevance 0.04
It regulates the stability of key proteins, including the KIT oncoproteins, important in oncogenesis, cancer cell proliferation, and cancer cell survival and plays a central role in protein folding in response to various environmental stresses.64 Pre-clinical work involving cell line models using 17-allylamino-18-demethoxy-geldanamycin (17-AAG), an inhibitor of the HSP90 chaperone protein, demonstrated significant reduction of both phospho- and total KIT expression, inactivation of downstream signaling pathways and inhibition of cellular proliferation and survival in both imatinib-sensitive and imatinib-resistant KIT-positive cell lines.
Negative_regulation (reduction) of Gene_expression (expression) of KIT associated with stress, cancer and hyperplasia
12) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.95 Pain Relevance 0
Although similar in size and shape to fibroblasts, they can be distinguished by immunohistochemistry according to the expression of both unphosphorylated connexin 43 and KIT and by a lack of expression of prolyl 4-hydroxlase.
Negative_regulation (distinguished) of Gene_expression (expression) of KIT in fibroblasts
13) Confidence 0.25 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0.09 Pain Relevance 0
The decline of miR-221 and miR-222 during exponential erythropoietic growth unblocked Kit protein production at mRNA level, thus leading to expansion of early erythroblasts [26].
Negative_regulation (decline) of Gene_expression (production) of Kit in early erythroblasts
14) Confidence 0.24 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.74 Pain Relevance 0
Ethanol significantly reduced the numbers of cells expressing the stem cell markers CD117, CD133, Sca-1 and ABCG2, without decreasing nestin expression.
Negative_regulation (reduced) of Gene_expression (expressing) of CD117 in stem cell
15) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1249578 Disease Relevance 0.16 Pain Relevance 0.04
These data suggest that while ethanol may not decrease the overall size of the precursor pool (the combined stem and blast pool, indicated by constant nestin mRNA expression), it decreases the diversity of stem cells within this pool (indicated by decreased numbers of cells expressing Sca-1, c-kit, CD133 and ABCG2).


Negative_regulation (numbers) of Gene_expression (expressing) of c-kit in stem
16) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
On the other hand, ethanol induced asymmetric division in progenitor cells and decreased the cell surface expression of a number of stem cell markers, i.e., c-kit/CD117, Sca-1 (Ly6A/E), CD133/prominin-1 and the ABCG2 transporter.
Negative_regulation (decreased) of Gene_expression (expression) of c-kit in stem cell
17) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.48 Pain Relevance 0.07
On the other hand, ethanol induced asymmetric division in progenitor cells and decreased the cell surface expression of a number of stem cell markers, i.e., c-kit/CD117, Sca-1 (Ly6A/E), CD133/prominin-1 and the ABCG2 transporter.
Negative_regulation (decreased) of Gene_expression (expression) of CD117 in stem cell
18) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.48 Pain Relevance 0.07
Sunitinib (SUN) is an orally bioavailable small molecule that inhibits multiple tyrosine kinases including all the PDGF receptors and VEGF receptors, as well as c-kit, RET, CSF-1R, and flt-3.
Negative_regulation (inhibits) of Gene_expression (receptors) of c-kit
19) Confidence 0.08 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.36 Pain Relevance 0.04
Recently, the introduction of epidermal growth factor receptor (EGFR) inhibitors, such as cetuximab, together with PBT, has improved response and survival rates in these patients (Vermorken et al, 2008).
Negative_regulation (inhibitors) of Gene_expression (introduction) of PBT
20) Confidence 0.05 Published 2010 Journal Br J Cancer Section Body Doc Link PMC2883700 Disease Relevance 0.71 Pain Relevance 0.07

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