INT187005

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 8.02
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
neurons 2
brain 2
Ghrh (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 12 93.44 High High
GABAergic 18 90.80 High High
antagonist 47 74.00 Quite High
Thoracotomy 14 46.96 Quite Low
Somatostatin 113 30.80 Quite Low
agonist 16 30.00 Quite Low
Action potential 44 27.08 Quite Low
Central nervous system 2 26.88 Quite Low
Neuropeptide 6 14.64 Low Low
Calcium channel 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 63 99.54 Very High Very High Very High
Metastasis 105 98.88 Very High Very High Very High
Galactorrhea 28 97.36 Very High Very High Very High
Reprotox - General 2 1 97.32 Very High Very High Very High
Targeted Disruption 27 95.28 Very High Very High Very High
Reprotox - General 3 1 94.92 High High
Carcinoid 140 93.72 High High
Acromegaly 126 92.76 High High
Cancer 329 90.88 High High
Pituitary Cancer 42 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of NPY neurons may not be limited to the feeding circuits, per se, since GHRH neurons express NPY Y2 receptors which mediate the downregulation of GHRH mRNA induced by long term fasting in rodents [25], [26].
Positive_regulation (neurons) of Gene_expression (neurons) of GHRH in neurons
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0.14 Pain Relevance 0.26
Superfusion of a GHRH-GFP brain slice with 10 µM U-73122, a phospholipase C inhibitor [38]–[40], enhanced the firing rate of GHRH neurons, from ?
Positive_regulation (enhanced) of Gene_expression (neurons) of GHRH in brain
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0
Nevertheless, in patient 3 GHRH levels increased slowly, suggesting growing metastasis under octreotide restraint.
Positive_regulation (increased) of Gene_expression (levels) of GHRH associated with metastasis
3) Confidence 0.43 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.72 Pain Relevance 0.04
Specific dynamical tests for GH excess do not allow classification with certainty in either category, although most patients with ectopic GHRH syndrome exhibit a paradoxical increase of GH after TRH and glucose (i.e. >50%) and a blunted GH rise (<100%) after exogenous GHRH injection [33].
Positive_regulation (after) of Gene_expression (injection) of GHRH associated with syndrome
4) Confidence 0.37 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.24 Pain Relevance 0
In addition, most patients also exhibit a moderate increase in serum prolactin concentration, which regresses after removal of the ectopic GHRH source, supporting the notion that GHRH is directly responsible for the hyperprolactinemia, a finding also present in hGHRH-transgenic mice [34].
Positive_regulation (regresses) of Gene_expression (source) of GHRH associated with targeted disruption and galactorrhea
5) Confidence 0.37 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.33 Pain Relevance 0
Specific dynamical tests for GH excess do not allow classification with certainty in either category, although most patients with ectopic GHRH syndrome exhibit a paradoxical increase of GH after TRH and glucose (i.e. >50%) and a blunted GH rise (<100%) after exogenous GHRH injection [33].
Positive_regulation (increase) of Gene_expression (injection) of GHRH associated with syndrome
6) Confidence 0.37 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.28 Pain Relevance 0
g) administration in both patients, the decrease in serum GH concentration in patient 2 after GHRH (50 ?
Positive_regulation (after) of Gene_expression (concentration) of GHRH
7) Confidence 0.37 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.51 Pain Relevance 0
Specific dynamical tests for GH excess do not allow classification with certainty in either category, although most patients with ectopic GHRH syndrome exhibit a paradoxical increase of GH after TRH and glucose (i.e. >50%) and a blunted GH rise (<100%) after exogenous GHRH injection [33].
Positive_regulation (exogenous) of Gene_expression (injection) of GHRH associated with syndrome
8) Confidence 0.37 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.24 Pain Relevance 0
Specific dynamical tests for GH excess do not allow classification with certainty in either category, although most patients with ectopic GHRH syndrome exhibit a paradoxical increase of GH after TRH and glucose (i.e. >50%) and a blunted GH rise (<100%) after exogenous GHRH injection [33].
Positive_regulation (after) of Gene_expression (injection) of GHRH associated with syndrome
9) Confidence 0.37 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.27 Pain Relevance 0
Such mice are unable to produce gonadotrophin releasing hormone (GnRH) due to a truncation in the GnRH gene, and therefore show a profound hypogonadotrophic hypogonadism [[5] for review].
Positive_regulation (truncation) of Neg (unable) Gene_expression (produce) of releasing hormone associated with reprotox - general 2
10) Confidence 0.04 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1249589 Disease Relevance 0.28 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox