INT187022

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.27
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
multinucleated giant cells 2
bladder 2
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 109 87.68 High High
Inflammation 6 80.40 Quite High
cytokine 1 62.48 Quite High
cva 1 55.00 Quite High
Hippocampus 2 6.00 Low Low
Pain 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 29 98.72 Very High Very High Very High
Giant Cell Tumors 34 98.40 Very High Very High Very High
Cancer 79 97.08 Very High Very High Very High
Fibrosarcoma 4 96.00 Very High Very High Very High
INFLAMMATION 11 94.56 High High
Necrosis 3 91.12 High High
Wrinkles 3 90.00 High High
Metastasis 19 89.52 High High
Pathologic Processes 1 88.88 High High
Giant Cell Granuloma 12 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kanayama et al. [33] found an elevated mRNA expression of MMP2 and MMP9 in tissue of muscular invasive bladder tumours compared to non-invasive tumours.
Positive_regulation (elevated) of Transcription (expression) of MMP9 in bladder associated with cancer and bladder cancer
1) Confidence 0.45 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.12 Pain Relevance 0.16
In addition, CCOS is able to reduce the expression of MMP-9 by downregulating the MMP-9 at transcription level, mediated via the inhibition of AP-1 [63].
Positive_regulation (mediated) of Transcription (transcription) of MMP-9
2) Confidence 0.13 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.67 Pain Relevance 0.11
Studies suggest that TNF-alpha secreted by the multinucleated giant cells up-regulates MMP-9 expression in GCT stromal cells by the induction of certain transcription factors, which in turn enhanced the rate of transcription of MMP-9 gene.
Positive_regulation (enhanced) of Transcription (transcription) of MMP-9 in multinucleated giant cells associated with giant cell tumors
3) Confidence 0.03 Published 2005 Journal BMC Ear Nose Throat Disord Section Body Doc Link PMC1253509 Disease Relevance 1.48 Pain Relevance 0.06

General Comments

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