INT187026

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.05
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 29 100.00 Very High Very High Very High
Arthritis 5 99.92 Very High Very High Very High
cocaine 59 99.90 Very High Very High Very High
medulla 2 91.88 High High
Catecholamine 2 86.08 High High
Inflammation 5 84.40 Quite High
rheumatoid arthritis 63 84.24 Quite High
imagery 6 54.44 Quite High
ischemia 7 52.76 Quite High
abdominal pain 2 50.64 Quite High
Disease Link Frequency Relevance Heat
Arthritis 5 99.92 Very High Very High Very High
Apoptosis 3 98.64 Very High Very High Very High
Poisoning 2 98.32 Very High Very High Very High
Cancer 4 97.72 Very High Very High Very High
Stress 6 90.72 High High
Autoimmune Disease 4 88.40 High High
INFLAMMATION 6 84.40 Quite High
Rheumatoid Arthritis 63 84.24 Quite High
Infarction 32 77.12 Quite High
Atherosclerosis 6 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1, TIMP-1 and TIMP-2 by ELISA assay
Positive_regulation (by) of Gene_expression (assay) of TIMP-2
1) Confidence 0.47 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 0 Pain Relevance 0.03
Overexpression of TIMP-1 and TIMP-2 is associated with inhibition of apoptosis and invasive tumour growth [18-20].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of TIMP-2 associated with cancer and apoptosis
2) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.16 Pain Relevance 0.32
There is evidence that cocaine may enhance the renal cortical messenger RNA expression of tissue inhibitors of metalloproteinase-2 [8].
Positive_regulation (enhance) of Gene_expression (expression) of metalloproteinase-2 associated with metalloproteinase and cocaine
3) Confidence 0.02 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1253515 Disease Relevance 0.89 Pain Relevance 0.61

General Comments

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