INT187045

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.42
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Scgb1a1) extracellular space (Scgb1a1) extracellular region (Scgb1a1)
endoplasmic reticulum (Scgb1a1) cytoplasm (Scgb1a1)
Anatomy Link Frequency
Clara cell 3
Scgb1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 9 92.84 High High
Inflammation 98 86.04 High High
fibrosis 58 32.16 Quite Low
cytokine 14 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 8 93.88 High High
Targeted Disruption 25 93.72 High High
Asthma 24 92.00 High High
Obesity 20 89.52 High High
INFLAMMATION 96 86.04 High High
Exsanguination 2 78.84 Quite High
Body Weight 2 69.28 Quite High
Sprains And Strains 6 68.08 Quite High
Adenocarcinoma 1 62.64 Quite High
Skin Cancer 4 59.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B mutant [15] under the regulation of rat Clara cell secretory protein (CCSP) promoter [21].
Regulation (regulation) of CCSP in Clara cell
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.40 Pain Relevance 0.08
B mutant [15] under the regulation of rat Clara cell secretory protein (CCSP) promoter [21].
Regulation (regulation) of Clara cell secretory protein in Clara cell
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.40 Pain Relevance 0.08
Another possible explanation for the lack of a clear relationship between serum CC16 and the O3 dose in the present study is that the time period between the measurements was not long enough to cause a measurable change in CC16 levels.
Regulation (change) of CC16
3) Confidence 0.36 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0 Pain Relevance 0
In those studies, the serum levels of CC16 in children did not change significantly during swimming exercise.
Neg (not) Regulation (change) of CC16
4) Confidence 0.36 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.09 Pain Relevance 0
Constitutive Cre recombinase expression has been targeted to Clara cells via the Clara cell secretory protein (CCSP) promoter, type II alveolar cells via the surfactant protein-C (SP-C) promoter, ciliated epithelial cells via the FoxJ1 promoter 8-11, and less specifically by an adenoviral Cre recombinase vector 12.
Regulation (targeted) of Clara cell secretory protein in Clara cell
5) Confidence 0.32 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2815352 Disease Relevance 0.35 Pain Relevance 0
A possible effect of ambient O3 on serum CC16 levels (in nonswimming children) needs further investigation.



Spec (possible) Regulation (effect) of CC16
6) Confidence 0.22 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0.18 Pain Relevance 0.04
Two CC16 values were available for 20 pool visitors and 31 non-pool visitors.
Regulation (values) of CC16
7) Confidence 0.22 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253671 Disease Relevance 0 Pain Relevance 0.09

General Comments

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