INT187050

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.92
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (RENBP)
Anatomy Link Frequency
plasma 1
amoeba 1
Adipocytes 1
RENBP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 100.00 Very High Very High Very High
Central nervous system 32 95.96 Very High Very High Very High
Inflammation 123 88.84 High High
rheumatoid arthritis 19 68.60 Quite High
Multiple sclerosis 2 66.72 Quite High
Inflammatory response 10 60.20 Quite High
medulla 2 46.64 Quite Low
midbrain 2 46.20 Quite Low
cva 3 38.12 Quite Low
headache 2 31.96 Quite Low
Disease Link Frequency Relevance Heat
Viral Meningitis 84 100.00 Very High Very High Very High
Meningoencephalitis 66 99.78 Very High Very High Very High
Obesity 141 99.74 Very High Very High Very High
Aspergillus Infection 2 96.60 Very High Very High Very High
Pseudomonas Infection 2 95.32 Very High Very High Very High
Disease 61 94.56 High High
Congenital Anomalies 22 91.36 High High
Increased Venous Pressure Under Development 19 89.16 High High
INFLAMMATION 151 88.84 High High
Vascular Disease 1 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Cox regression was adjusted for age, gender, HD age, calcium and PTH.
Localization (calcium) of age
1) Confidence 0.35 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.20 Pain Relevance 0
The Cox regression was adjusted for age, gender, HD age, calcium and PTH.
Localization (calcium) of age
2) Confidence 0.35 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.20 Pain Relevance 0
The samples were blinded with only sex and age noted, and stored at ?
Localization (stored) of age
3) Confidence 0.08 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 1.55 Pain Relevance 0.10
The samples were blinded with only sex and age noted, and stored at ?
Localization (sex) of age
4) Confidence 0.08 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 1.54 Pain Relevance 0.10
When they are not eliminated by the kidneys, recirculating AGE peptides can generate new AGEs reacting with plasma or tissue components.
Localization (recirculating) of AGE in plasma
5) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.40 Pain Relevance 0
The present study examines Acanthamoeba proteases released extracellularly by an AGE isolate to begin to ask if these proteases could be involved in this amoeba's ability to invade the CNS.
Localization (released) of AGE in amoeba associated with meningoencephalitis, central nervous system and viral meningitis
6) Confidence 0.02 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.72 Pain Relevance 0.23
In summary, these data show that both serine and metalloproteases secreted by AGE isolate (T1 genotype), exhibit properties to degrade ECM, which may facilitate amoebic invasion of the deeper lying tissues of the CNS.
Localization (secreted) of AGE associated with central nervous system and viral meningitis
7) Confidence 0.02 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.78 Pain Relevance 0.05
Adipocytes express and secrete a variety of adipokines including cytokines, growth factors, adiponectin, resistin, adipsin, leptin, acylation stimulating protein, plasminogen activator inhibitor-1 (PAI-1), lipoprotein lipase, and components of the renin-angiotensin system which may exert local (autocrine/paracrine) and systemic (endocrine) effects [67–69].

5.2.

Localization (secrete) of renin-angiotensin in Adipocytes associated with obesity and cytokine
8) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.53 Pain Relevance 0.13

General Comments

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