INT187087

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.79
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) Golgi apparatus (Cd44) plasma membrane (Cd44)
nucleus (Cd44) protein complex (Cd44) cytoplasm (Cd44)
Anatomy Link Frequency
plasma cells 1
leukocyte 1
Cd44 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 96.60 Very High Very High Very High
Arthritis 122 95.28 Very High Very High Very High
rheumatoid arthritis 63 87.16 High High
cytokine 39 75.80 Quite High
spinal inflammation 1 54.16 Quite High
tolerance 1 11.84 Low Low
chemokine 9 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 1 99.08 Very High Very High Very High
Arthritis 139 96.84 Very High Very High Very High
Cancer 357 92.80 High High
Adhesions 15 92.48 High High
Residual Neoplasm 20 91.20 High High
Colorectal Cancer 64 88.88 High High
Rheumatoid Arthritis 63 87.16 High High
Osteoarthritis 4 84.20 Quite High
Apoptosis 8 83.24 Quite High
Low Back Pain 1 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD44 isoforms containing variable exon 3 (v3) have been shown to bind growth factors through HS side chains, thereby regulating cell growth and motility [74].
CD44 Binding (bind) of
1) Confidence 0.47 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.08 Pain Relevance 0
Support for this model comes from studies showing loss or inhibition of CD44 and VLA-4 (very late antigen-4) interactions with their ligands that can reduce leukocyte rolling interactions and inhibit joint inflammation in animal models of arthritis [19,20].
CD44 Binding (interactions) of in leukocyte associated with inflammation and arthritis
2) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.09 Pain Relevance 0.47
When tumorigenicity of CD44+ versus CD44?
CD44 Binding (tumorigenicity) of
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.55 Pain Relevance 0
, and ligands for CD44, can also prolong the longevity of plasma cells [56].
CD44 Binding (ligands) of in plasma cells associated with aging
4) Confidence 0.17 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC2833442 Disease Relevance 0.50 Pain Relevance 0.19
When tumorigenicity of CD44+ versus CD44?
CD44 Binding (tumorigenicity) of
5) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.56 Pain Relevance 0

General Comments

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