INT187089

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 10.00
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joint 2
B-lymphocytes 2
lymphocytes 2
Cia1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 869 100.00 Very High Very High Very High
rheumatoid arthritis 244 97.28 Very High Very High Very High
anesthesia 5 95.60 Very High Very High Very High
ketamine 3 92.32 High High
Inflammation 152 92.20 High High
addiction 3 72.68 Quite High
cytokine 131 72.00 Quite High
chemokine 25 70.88 Quite High
antagonist 12 54.00 Quite High
dexamethasone 4 46.28 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 955 100.00 Very High Very High Very High
Immunization 58 99.84 Very High Very High Very High
Arthropathy 22 99.84 Very High Very High Very High
Stress 7 97.68 Very High Very High Very High
Rheumatoid Arthritis 247 97.28 Very High Very High Very High
Sprains And Strains 19 97.20 Very High Very High Very High
Alagille Syndrome 1 96.92 Very High Very High Very High
Autoimmune Disease 31 96.68 Very High Very High Very High
Infection 16 96.08 Very High Very High Very High
Experimental Arthritis 7 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CIA induction and scoring for CIA development
Positive_regulation (induction) of Gene_expression (development) of CIA associated with arthritis
1) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.75 Pain Relevance 0.22
While our results in the mouse CIA model suggest a role of B7-H4 in pathogenesis of CIA, one should be cautious because the CIA model does not mimic human RA in all aspects, and it remains to be tested whether sH4 participates in the development of human RA.
Positive_regulation (role) of Gene_expression (pathogenesis) of CIA associated with rheumatoid arthritis and arthritis
2) Confidence 0.13 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.70 Pain Relevance 0.58
expression in joint tissue at several time points during the development of CIA, and increased LN cell production of both IL-1?
Positive_regulation (increased) of Gene_expression (production) of CIA in joint associated with arthritis
3) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.02 Pain Relevance 0.49
2 weeks after ovariectomy CIA was induced by immunization with 100 ?
Positive_regulation (induced) of Gene_expression (weeks) of CIA associated with immunization and arthritis
4) Confidence 0.08 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009959 Disease Relevance 0.87 Pain Relevance 0.40
2 weeks after ovariectomy CIA was induced by immunization with 100 ?
Positive_regulation (after) of Gene_expression (weeks) of CIA associated with immunization and arthritis
5) Confidence 0.08 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009959 Disease Relevance 0.87 Pain Relevance 0.39
Murine CIA experiment
Positive_regulation (Murine) of Gene_expression (experiment) of CIA associated with arthritis
6) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.58 Pain Relevance 0.21
Apremilast reduces severity of CIA in DBA/1 mice
Positive_regulation (severity) of Gene_expression (severity) of CIA associated with arthritis
7) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911898 Disease Relevance 1.00 Pain Relevance 0.38
Both CIA and PGIA can be adoptively transferred to syngeneic immunocompromised mice by lymphocytes isolated from arthritic donors [11-13].
Positive_regulation (transferred) of Gene_expression (transferred) of CIA in lymphocytes associated with arthritis
8) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.64 Pain Relevance 0.71
Indeed, activity of B-lymphocytes is absolutely required for CIA induction as joint disease does not develop in B-cell-deficient mice [120].
Positive_regulation (required) of Gene_expression (induction) of CIA in B-lymphocytes associated with arthropathy and arthritis
9) Confidence 0.02 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 1.57 Pain Relevance 0.74

General Comments

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