INT187090

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.16
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
Mouse 4
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 224 97.76 Very High Very High Very High
antagonist 7 65.92 Quite High
Inflammatory response 8 29.92 Quite Low
cytokine 70 15.92 Low Low
Pain 7 5.20 Low Low
Inflammation 40 5.00 Very Low Very Low Very Low
rheumatoid arthritis 26 5.00 Very Low Very Low Very Low
chemokine 16 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 16 100.00 Very High Very High Very High
Muscle Disease 23 98.96 Very High Very High Very High
Arthritis 254 97.76 Very High Very High Very High
Osteogenesis Imperfecta 112 97.76 Very High Very High Very High
Hypercalcemia 8 97.24 Very High Very High Very High
Osteochondrodysplasias 27 96.00 Very High Very High Very High
Stress 9 93.40 High High
Targeted Disruption 5 93.36 High High
Disease 54 91.36 High High
Muscle Weakness 7 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In severe and moderately severe OI (generally due to a structural defect of type I collagen synthesis) agents increasing the production of type I collagen, such as GH, do not represent a suitable treatment, other agents that reduce bone resorption, such as BPs, are preferable for their action in increasing BMC.
Positive_regulation (as) of Localization (such) of collagen associated with osteogenesis imperfecta and hypercalcemia
1) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.72 Pain Relevance 0
To test the hypothesis that myopathy is specifically associated with CTD-COMP mutations localised near the potential collagen and integrin binding sites, we have investigated a second mouse model, COMP ?
Positive_regulation (potential) of Localization (localised) of collagen associated with muscle disease
2) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 1.03 Pain Relevance 0
Mouse serum IgG anti-collagen antibody concentration after collagen immunization is not increased in selectin mutant compared with wild-type mice in pre-CIA onset mice
Neg (not) Positive_regulation (increased) of Localization (immunization) of collagen in Mouse associated with immunization and arthritis
3) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.70 Pain Relevance 0.25
Mouse serum IgG anti-collagen antibody concentration after collagen immunization is not increased in selectin mutant compared with wild-type mice in pre-CIA onset mice
Neg (not) Positive_regulation (increased) of Localization (immunization) of collagen in Mouse associated with immunization and arthritis
4) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.71 Pain Relevance 0.25

General Comments

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