INT187091

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 11.11
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
joints 1
monocytes 1
cartilage 1
Cia1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 694 100.00 Very High Very High Very High
Inflammation 188 100.00 Very High Very High Very High
metalloproteinase 23 99.88 Very High Very High Very High
rheumatoid arthritis 319 99.68 Very High Very High Very High
chemokine 39 99.56 Very High Very High Very High
cytokine 117 99.28 Very High Very High Very High
Demyelination 2 87.84 High High
Inflammatory mediators 5 85.12 High High
Multiple sclerosis 2 64.40 Quite High
imagery 12 63.92 Quite High
Disease Link Frequency Relevance Heat
Arthritis 650 100.00 Very High Very High Very High
INFLAMMATION 203 100.00 Very High Very High Very High
Experimental Arthritis 81 100.00 Very High Very High Very High
Immunization 68 100.00 Very High Very High Very High
Rheumatoid Arthritis 325 99.68 Very High Very High Very High
Disease 194 98.48 Very High Very High Very High
Pressure And Volume Under Development 69 96.68 Very High Very High Very High
Pulmonary Disease 5 92.40 High High
Asthma 1 92.04 High High
Infection 14 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP-3 is related to inflammation as well as cartilage and bone damage in CIA
Localization (related) of CIA in cartilage associated with inflammation, metalloproteinase and arthritis
1) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 0.66 Pain Relevance 0.47
, or that that these monocytes are specifically recruited to the joints of selectin deficient mice during CIA development.
Localization (recruited) of CIA in joints associated with arthritis
2) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.24 Pain Relevance 0.45
We quantified the Gr-1+ Mac-1+ neutrophils in peripheral blood in the CIA model on day 2 after primary collagen immunization.
Localization (immunization) of CIA in blood associated with immunization and arthritis
3) Confidence 0.20 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.22 Pain Relevance 0.29
Taken together, our data indicate the sH4-mediated exacerbation of CIA is dependent on Gr-1+ cells.
Localization (exacerbation) of CIA associated with arthritis
4) Confidence 0.20 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.09 Pain Relevance 0.52
After a boost immunization on Day 21, onset of CIA was assessed.
Localization (onset) of CIA associated with immunization and arthritis
5) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.09 Pain Relevance 0.32
As in CIA, the therapeutic efficacy of TNF?
Localization (efficacy) of CIA associated with arthritis
6) Confidence 0.07 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 1.36 Pain Relevance 0.33
Cytokine and chemokine protein detection in CIA synovial tissue
Localization (tissue) of CIA associated with chemokine, arthritis and cytokine
7) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.25 Pain Relevance 0.46
release from LPS-stimulated monocytes and rheumatoid synovial membrane cultures, we next evaluated its anti-arthritic potential in two independently executed, acute mouse models of arthritis, namely mAb-induced arthritis and CIA.
Localization (release) of CIA in monocytes associated with arthritis
8) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911898 Disease Relevance 1.19 Pain Relevance 0.44
Whilst heterologous (bovine) CIA provides a tried and tested mechanism for assessing therapeutics such as TNF-?
Localization (bovine) of CIA associated with arthritis
9) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246249 Disease Relevance 1.50 Pain Relevance 0.56
Whilst heterologous (bovine) CIA provides a tried and tested mechanism for assessing therapeutics such as TNF-?
Localization (heterologous) of CIA associated with arthritis
10) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246249 Disease Relevance 1.51 Pain Relevance 0.56

General Comments

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