INT187095

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.17
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 4
neutrophils 2
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 38 100.00 Very High Very High Very High
antagonist 24 99.92 Very High Very High Very High
Arthritis 130 99.60 Very High Very High Very High
rheumatoid arthritis 29 98.80 Very High Very High Very High
Inflammation 339 98.48 Very High Very High Very High
cytokine 190 96.48 Very High Very High Very High
Inflammatory response 46 76.56 Quite High
Inflammatory stimuli 2 58.44 Quite High
psoriasis 37 50.00 Quite Low
agonist 11 38.92 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 404 100.00 Very High Very High Very High
Crystal Associated Disease 30 100.00 Very High Very High Very High
Arthritis 139 99.60 Very High Very High Very High
Gingival Overgrowth 1 98.92 Very High Very High Very High
Disease 158 98.80 Very High Very High Very High
Rheumatoid Arthritis 32 98.80 Very High Very High Very High
Immune System Diseases 3 95.60 Very High Very High Very High
Otitis 2 93.92 High High
Otitis Media With Effusion 92 93.04 High High
Otitis Media 134 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings clearly underscore the importance of IL-1?
Negative_regulation (underscore) of Positive_regulation (importance) of IL-1
1) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.29 Pain Relevance 0.63
Many investigators reported upregulation of IL-1?
Negative_regulation (reported) of Positive_regulation (upregulation) of IL-1
2) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 0.82 Pain Relevance 0.15
Administration of apocynin, widely used as a NADPH oxidase inhibitor, partially reduced the accumulation of IL-1?
Negative_regulation (reduced) of Positive_regulation (accumulation) of IL-1
3) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.21 Pain Relevance 0.07
In a previous study cyclosporine induced IL-1?
Negative_regulation (cyclosporine) of Positive_regulation (induced) of IL-1
4) Confidence 0.06 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 0.30 Pain Relevance 0.07
In addition, the anti-inflammatory effects of flavonoids seem to be related to a decrease of neutrophils infiltration, absence of upregulation of IL-1?
Negative_regulation (absence) of Positive_regulation (upregulation) of IL-1 in neutrophils associated with inflammation
5) Confidence 0.05 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810372 Disease Relevance 0.74 Pain Relevance 0.10
However, in ongoing investigations into the effects of the extracts on inflammatory mediator synthesis by cultured murine macrophages, we have detected a >95% reduction of MSU crystal-induced IL-1?
Negative_regulation (reduction) of Positive_regulation (induced) of IL-1 in macrophages associated with inflammation and crystal associated disease
6) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.52 Pain Relevance 0.20
Inhibiting the production of the undesirable excess of pro-inflammatory mediators such as IL-1?
Negative_regulation (Inhibiting) of Positive_regulation (mediators) of IL-1 associated with inflammatory mediators
7) Confidence 0.03 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 1.40 Pain Relevance 0.52
Cultured monocytes, which had differentiated to macrophages, had a markedly reduced LPS inducible IL-1, but not TNF-?
Negative_regulation (reduced) of Neg (not) Positive_regulation (inducible) of IL-1 in macrophages
8) Confidence 0.02 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.89 Pain Relevance 0.08

General Comments

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