INT187096

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.92
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) Golgi apparatus (Cd44) plasma membrane (Cd44)
nucleus (Cd44) protein complex (Cd44) cytoplasm (Cd44)
Anatomy Link Frequency
neuronal 1
leukocyte 1
apoptotic cells 1
stem cell 1
neutrophils 1
Cd44 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 26 99.04 Very High Very High Very High
Inflammation 113 94.80 High High
Arthritis 113 93.48 High High
Central nervous system 36 91.88 High High
rheumatoid arthritis 17 85.56 High High
cytokine 99 84.64 Quite High
Spinal cord 6 72.48 Quite High
cINOD 3 26.16 Quite Low
Multiple sclerosis 17 18.88 Low Low
chemokine 37 18.84 Low Low
Disease Link Frequency Relevance Heat
Scoliosis 314 99.44 Very High Very High Very High
Targeted Disruption 19 99.08 Very High Very High Very High
Cv Unclassified Under Development 26 99.04 Very High Very High Very High
Cancer 145 98.92 Very High Very High Very High
Apoptosis 40 98.66 Very High Very High Very High
Arthritis 128 95.04 Very High Very High Very High
Malignant Neoplastic Disease 29 93.56 High High
Adhesions 32 93.04 High High
Central Nervous System Disease 6 91.88 High High
Injury 164 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Support for this model comes from studies showing loss or inhibition of CD44 and VLA-4 (very late antigen-4) interactions with their ligands that can reduce leukocyte rolling interactions and inhibit joint inflammation in animal models of arthritis [19,20].
Negative_regulation (inhibition) of CD44 in leukocyte associated with inflammation and arthritis
1) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.03 Pain Relevance 0.43
While the percentage of apoptotic cells was again unaltered, surface expression levels of LFA-1 and CD44 were reduced on Th cells from CpdA treated mice in a dose-dependent manner (Fig. 6B).
Negative_regulation (reduced) of CD44 in apoptotic cells associated with apoptosis
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.89 Pain Relevance 0.17
CD44 deficiency or administration of anti-CD44 to mice reduced the influx of neutrophils into the postischemic tissue, associated with renal function preservation [97].
Negative_regulation (deficiency) of CD44 in neutrophils
3) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.00 Pain Relevance 0.08
The anatomical distribution of Cd44 (probed for the five first exons) and Ch25h was quite identical, but very different from Stat1 (neuronal-like) and Il1b.
Negative_regulation (distribution) of Cd44 in neuronal
4) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.06 Pain Relevance 0.03
The loss of CD44 in the heterotransplanted tumor sections may be explained by the presence of factors that increase the differentiation of USC-HN1 in situ in contrast to its stem cell-like phenotype that predominates in cell culture or in vivo [8].
Negative_regulation (loss) of CD44 in stem cell associated with cancer
5) Confidence 0.18 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.92 Pain Relevance 0
CD44 staining is decreased in the heterotransplant and cytospin in comparison with the original tumor biopsy.


Negative_regulation (decreased) of CD44 associated with cancer
6) Confidence 0.17 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.83 Pain Relevance 0
Deficiency of osteopontin or CD44 receptor also protect transgenic melatonin-deficient C57Bl/6J mice from scoliosis [19,20].
Negative_regulation (Deficiency) of CD44 associated with scoliosis and targeted disruption
7) Confidence 0.13 Published 2009 Journal Scoliosis Section Body Doc Link PMC2781798 Disease Relevance 1.20 Pain Relevance 0

General Comments

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