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Context Info
Confidence 0.60
First Reported 1981
Last Reported 1998
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.79
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
neuron 2
brain 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 2 99.78 Very High Very High Very High
Clonidine 9 98.64 Very High Very High Very High
addiction 1 91.32 High High
narcan 3 90.52 High High
noradrenaline 2 90.08 High High
Neurotransmitter 2 87.00 High High
agonist 9 79.92 Quite High
Morphine 2 75.00 Quite High
antagonist 1 73.64 Quite High
Intracerebroventricular 1 59.28 Quite High
Disease Link Frequency Relevance Heat
Stress 8 99.38 Very High Very High Very High
Pressure Volume 2 Under Development 2 81.48 Quite High
Adrenal Insufficiency 1 60.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support a role for neuronal feedback in regulation of the CRH neuron.
Regulation (role) of Regulation (regulation) of CRH in neuron
1) Confidence 0.60 Published 1990 Journal Endocrinology Section Abstract Doc Link 2171915 Disease Relevance 0 Pain Relevance 0.08
In contrast to CRH gene regulation, PVHmpd proenkephalin mRNA levels were unaffected by corticosterone concentrations.
Neg (unaffected) Regulation (unaffected) of Regulation (regulation) of CRH gene
2) Confidence 0.44 Published 1998 Journal Endocrinology Section Abstract Doc Link 9724036 Disease Relevance 0.28 Pain Relevance 0
These findings are consistent with a role for brain endorphins in the regulation of CRF release.
Regulation (role) of Regulation (regulation) of CRF in brain
3) Confidence 0.44 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6270585 Disease Relevance 0 Pain Relevance 0.16
Neither social stress nor endogenous prostaglandins affected the responsiveness of the CRH system.
Neg (Neither) Regulation (affected) of Regulation (responsiveness) of CRH associated with stress
4) Confidence 0.27 Published 1996 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9116324 Disease Relevance 0.52 Pain Relevance 0.34
These data suggest differential roles for alpha-1 and alpha-2 systems in the regulation of corticotropin-releasing factor.
Regulation (roles) of Regulation (regulation) of corticotropin-releasing factor
5) Confidence 0.23 Published 1990 Journal Neuroscience Section Abstract Doc Link 1980144 Disease Relevance 0 Pain Relevance 0.65
Neuropeptide Y-induced effects on hypothalamic corticotropin-releasing factor content and release are dependent on noradrenergic/adrenergic neurotransmission.
Regulation (dependent) of Regulation (effects) of hypothalamic corticotropin-releasing factor associated with neuropeptide
6) Confidence 0.11 Published 1989 Journal Brain Res. Section Title Doc Link 2551461 Disease Relevance 0 Pain Relevance 0.36

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