INT187105

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2, MMP9) peptidase activity (MMP9) extracellular space (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
bar 4
TIMP2 (Homo sapiens)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 126 67.28 Quite High
metalloproteinase 52 55.16 Quite High
methotrexate 10 50.40 Quite High
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
Leflunomide 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 126 67.28 Quite High
Arthropathy 14 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Autoimmune Disease 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Rupture 4 5.00 Very Low Very Low Very Low
Chondrocalcinosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the concentrations used, TIMP-2 totally abolished activation of MMP9, diminishing hydrolysis of S-2444 substrate from 100% to 7% (Fig. 4, bar 2).
TIMP-2 Negative_regulation (diminishing) of Positive_regulation (activation) of MMP9 in bar
1) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.18 Pain Relevance 0.14
At the concentrations used, TIMP-2 totally abolished activation of MMP9, diminishing hydrolysis of S-2444 substrate from 100% to 7% (Fig. 4, bar 2).
TIMP-2 Negative_regulation (abolished) of Positive_regulation (activation) of MMP9 in bar
2) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.18 Pain Relevance 0.14

General Comments

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