INT187116

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.37
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2, MMP9) peptidase activity (MMP9) extracellular space (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
TIMP2 (Homo sapiens)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 126 98.58 Very High Very High Very High
Arthritis 10 87.28 High High
cytokine 4 77.64 Quite High
Inflammation 8 77.28 Quite High
metalloproteinase 52 50.00 Quite Low
methotrexate 10 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
Leflunomide 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 126 98.58 Very High Very High Very High
Arthropathy 14 89.20 High High
Experimental Arthritis 2 87.28 High High
Autoimmune Disease 6 80.88 Quite High
INFLAMMATION 10 77.28 Quite High
Apoptosis 6 60.08 Quite High
Cancer 8 57.08 Quite High
Arthritis 10 49.00 Quite Low
Disease 8 5.00 Very Low Very Low Very Low
Rupture 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, immunoglobulins containing TIMP-2 antibodies purified from RA patients were proved to be functionally active by preventing in vitro TIMP-2-dependent inactivation of MMP9.
TIMP-2 Negative_regulation (inactivation) of MMP9 associated with rheumatoid arthritis
1) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.60 Pain Relevance 0.21
Importantly, we showed that TIMP-2 antibodies purified from RA patients were functionally active, since they were able to neutralize TIMP-2-mediated inhibition of MMP9.
TIMP-2-mediated Negative_regulation (inhibition) of MMP9 associated with rheumatoid arthritis
2) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.77 Pain Relevance 0.29

General Comments

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