INT187117

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2, MMP9) peptidase activity (MMP9) extracellular space (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
TIMP2 (Homo sapiens)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 63 98.98 Very High Very High Very High
metalloproteinase 26 50.00 Quite Low
Arthritis 5 41.12 Quite Low
Inflammation 4 40.00 Quite Low
methotrexate 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
Leflunomide 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 63 98.98 Very High Very High Very High
Arthropathy 7 89.20 High High
Autoimmune Disease 3 80.88 Quite High
Arthritis 5 41.12 Quite Low
INFLAMMATION 5 40.00 Quite Low
Disease 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Rupture 2 5.00 Very Low Very Low Very Low
Chondrocalcinosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, immunoglobulins containing TIMP-2 antibodies purified from RA patients were proved to be functionally active by preventing in vitro TIMP-2-dependent inactivation of MMP9.
Negative_regulation (preventing) of TIMP-2 Negative_regulation (inactivation) of MMP9 associated with rheumatoid arthritis
1) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.60 Pain Relevance 0.22

General Comments

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