INT187123

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.54
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 38 99.90 Very High Very High Very High
metalloproteinase 119 97.84 Very High Very High Very High
Inflammation 65 83.04 Quite High
rheumatoid arthritis 126 81.28 Quite High
Inflammatory mediators 3 70.36 Quite High
methotrexate 10 64.40 Quite High
Inflammatory stimuli 1 55.04 Quite High
ischemia 24 7.76 Low Low
cytokine 28 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Angina 34 99.90 Very High Very High Very High
Cancer 46 95.28 Very High Very High Very High
Acute Coronary Syndrome 70 92.92 High High
Disease 19 89.72 High High
Bladder Cancer 29 88.76 High High
Rupture 20 87.76 High High
INFLAMMATION 74 83.04 Quite High
Renal Cancer 4 82.88 Quite High
Rheumatoid Arthritis 126 81.28 Quite High
Aggression 2 72.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the AA-induced activity of MMP-9 did not diminish in the presence of n-3 fatty acids, although the cellular fatty acid content revealed an ample availability of n-3 fatty acids after incubation.
Neg (not) Negative_regulation (diminish) of Positive_regulation (induced) of MMP-9
1) Confidence 0.42 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.08 Pain Relevance 0.04
Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].
Negative_regulation (inhibited) of Positive_regulation (Activated) of MMP9 associated with metalloproteinase
2) Confidence 0.38 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.89 Pain Relevance 0.23
Serial dilutions of recombinant TIMP-2 were assessed with respect to their effect on MMP9 activity, and the lowest amount of TIMP-2 totally abolishing the activation of MMP9 was used in further experiments.
Negative_regulation (abolishing) of Positive_regulation (activation) of MMP9
3) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.22 Pain Relevance 0.18
The ability of TIMP-2/IgG mixtures to prevent the activation of MMP9 was monitored.
Negative_regulation (prevent) of Positive_regulation (activation) of MMP9
4) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.20 Pain Relevance 0.16
As shown in Fig 5, Ly 294002 blocked the induction of MMP-9 by AA and PMA in a dose-dependent manner.
Negative_regulation (blocked) of Positive_regulation (induction) of MMP-9
5) Confidence 0.36 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
g/mL of either PHT or HPPH prior to LPS stimulation prevented a significant increase in MMP-9 and TIMP-1 (Fig. 1D and Fig. 2).
Negative_regulation (prevented) of Positive_regulation (increase) of MMP-9
6) Confidence 0.10 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0
Patients with stable angina had a MMP-9 concentration similar to healthy controls; all patients with UA had elevated levels of MMP-9 at entry, that decreased gradually during hospitalization.
Negative_regulation (decreased) of Positive_regulation (elevated) of MMP-9 associated with angina
7) Confidence 0.06 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.14 Pain Relevance 0.56

General Comments

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