INT187128

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.43
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
Anatomy Link Frequency
a band 2
bladder 1
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 441 99.74 Very High Very High Very High
Arthritis 35 96.56 Very High Very High Very High
metalloproteinase 240 96.40 Very High Very High Very High
cytokine 14 86.92 High High
Inflammation 34 86.56 High High
methotrexate 35 5.04 Very Low Very Low Very Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
Infliximab 7 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
Etanercept 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 28 100.00 Very High Very High Very High
Rheumatoid Arthritis 441 99.74 Very High Very High Very High
Transitional Cell Carcinoma 26 98.24 Very High Very High Very High
Experimental Arthritis 7 96.56 Very High Very High Very High
Bladder Cancer 29 92.36 High High
Benign Prostatic Hypertrophy 115 90.40 High High
Cancer 106 89.48 High High
Arthropathy 49 86.72 High High
INFLAMMATION 41 86.56 High High
Aggression 4 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunoglobulins isolated from a patient with RA having high reactivity with TIMP-2, as detected by ELISA, recognized a protein of molecular weight 22 kDa corresponding to TIMP-2 forming a band in the blotting membrane.


TIMP-2 Binding (reactivity) of in a band associated with rheumatoid arthritis
1) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.65 Pain Relevance 0.30
Neutralization of TIMP-2 activity by antibodies from RA patients
TIMP-2 Binding (activity) of associated with rheumatoid arthritis
2) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.26 Pain Relevance 0.10
All these experimental data further support our findings on the immunomodulatory role of antibodies against TIMP-1 and TIMP-2 in patients with RA.
TIMP-2 Binding (findings) of associated with rheumatoid arthritis
3) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.91 Pain Relevance 0.34
Importantly, immunoglobulins containing TIMP-2 antibodies purified from RA patients were proved to be functionally active by preventing in vitro TIMP-2-dependent inactivation of MMP9.
TIMP-2 Binding (preventing) of associated with rheumatoid arthritis
4) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.59 Pain Relevance 0.21
The functional activity of IgG from RA patients against TIMP was assessed by incubating TIMP-2 (2.5 ng) with increasing amounts (0 ?
TIMP-2 Binding (incubating) of associated with rheumatoid arthritis
5) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.26 Pain Relevance 0.10
Extracellular stimulation with TIMP-1 and TIMP-2 is recognized by specific surface receptors and activates cascades dependent on mitogen-activated protein kinase (MAPK) and on tyrosine kinase [22].
TIMP-2 Binding (recognized) of
6) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.03 Pain Relevance 0.37
The immunoglobulins isolated from a patient with RA having high reactivity with TIMP-2, as detected by ELISA, recognized a protein of molecular weight 22 kDa corresponding to TIMP-2 forming a band in the blotting membrane.


TIMP-2 Binding (recognized) of in a band associated with rheumatoid arthritis
7) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.68 Pain Relevance 0.31
Gakiopoulou et al. [36] found that TIMP2 is involved in regulation of apoptosis and is associated with an adverse prognosis in patients with TCC of the bladder.
TIMP2 Binding (associated) of in bladder associated with apoptosis and transitional cell carcinoma
8) Confidence 0.30 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.21 Pain Relevance 0.18
The immunostaining for TIMP2, FGF2, and SMOC1 was often quite marked.
TIMP2 Binding (immunostaining) of
9) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.78 Pain Relevance 0
The dissociation of cysteine from the Zn2+ atom, known as “cysteine switch,” is a complex process, the details of which have emerged only recently10 The activity of mmps is specifically inhibited by tissue inhibitors of mmps (timps: timp-1, timp-2, timp-3, and timp-4), which usually bind to the active species, inhibiting catalysis.
timp-2 Binding (bind) of
10) Confidence 0.08 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 0.05 Pain Relevance 0
It is now known that, for example, low concentrations of timp-2 can promote activation of pro-mmp-2 through a mechanism in which timp-2 acts as a linker between the pro-mmp-2 zymogen and mt1-mmp at the cell surface.
timp-2 Binding (linker) of
11) Confidence 0.05 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 0 Pain Relevance 0

General Comments

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