INT187130

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 63 98.80 Very High Very High Very High
Arthritis 5 87.72 High High
cytokine 2 78.08 Quite High
Inflammation 4 77.72 Quite High
metalloproteinase 26 50.00 Quite Low
methotrexate 5 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
Leflunomide 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 63 98.80 Very High Very High Very High
Experimental Arthritis 1 87.72 High High
INFLAMMATION 5 77.72 Quite High
Apoptosis 3 60.52 Quite High
Cancer 4 57.52 Quite High
Arthritis 5 49.44 Quite Low
Autoimmune Disease 3 37.92 Quite Low
Arthropathy 7 9.36 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Rupture 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, we showed that TIMP-2 antibodies purified from RA patients were functionally active, since they were able to neutralize TIMP-2-mediated inhibition of MMP9.
Positive_regulation (neutralize) of Negative_regulation (inhibition) of TIMP-2-mediated associated with rheumatoid arthritis
1) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.78 Pain Relevance 0.29

General Comments

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