INT187135

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.87
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 148 100.00 Very High Very High Very High
rheumatoid arthritis 79 98.80 Very High Very High Very High
Arthritis 48 96.16 Very High Very High Very High
Inflammation 25 91.32 High High
Pain 1 90.64 High High
cytokine 9 78.08 Quite High
Osteoarthritis 19 76.96 Quite High
methotrexate 6 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 79 98.80 Very High Very High Very High
Arthritis 53 96.16 Very High Very High Very High
Fibrosarcoma 3 96.08 Very High Very High Very High
INFLAMMATION 21 91.32 High High
Arthralgia 1 90.64 High High
Experimental Arthritis 1 87.72 High High
Osteoarthritis 20 76.96 Quite High
Disease 17 69.44 Quite High
Cancer 15 68.08 Quite High
Stress 1 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, we showed that TIMP-2 antibodies purified from RA patients were functionally active, since they were able to neutralize TIMP-2-mediated inhibition of MMP9.
Positive_regulation (neutralize) of Negative_regulation (inhibition) of MMP9 associated with rheumatoid arthritis
1) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.78 Pain Relevance 0.29
Also, although the expression level of MMP-9 is not indicative of the NPA found in SF, MMPs contribute to a large extent to the proteolytic activity.
Neg (not) Positive_regulation (indicative) of Negative_regulation (level) of MMP-9 associated with metalloproteinase
2) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.53 Pain Relevance 0.40
Expression and activity of above MMPs studied suggested SG as a potent MMP inhibitor, and inhibition of MMP-2 and MMP-9 was due to down-regulation of transcription factor, NF-?
Positive_regulation (due) of Negative_regulation (inhibition) of MMP-9 associated with metalloproteinase
3) Confidence 0.26 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.56 Pain Relevance 0.23

General Comments

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