INT187153

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.25
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CXCR3) plasma membrane (CXCR3) cytoplasm (CXCR3)
signal transducer activity (CXCR3)
Anatomy Link Frequency
memory B cells 2
T-cell 2
CXCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 263 97.12 Very High Very High Very High
cytokine 5 83.92 Quite High
rheumatoid arthritis 124 77.64 Quite High
Inflammation 46 62.40 Quite High
Inflammatory mediators 1 56.28 Quite High
Inflammatory response 1 48.32 Quite Low
Osteoarthritis 38 29.60 Quite Low
antagonist 9 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 1 98.70 Very High Very High Very High
Cancer 160 98.24 Very High Very High Very High
Systemic Lupus Erythematosus 78 97.56 Very High Very High Very High
Malignant Neoplastic Disease 16 90.68 High High
Metastasis 18 86.52 High High
Melanoma 5 86.08 High High
Rheumatoid Arthritis 124 77.64 Quite High
INFLAMMATION 51 62.40 Quite High
Ovarian Cancer 85 50.00 Quite Low
Hypoxia 1 49.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a transmigration assay we were able to show that low levels of CXCR3 expression are sufficient to permit a response to the migrational stimulus of the chemokine CXCL10.
Negative_regulation (levels) of Gene_expression (expression) of CXCR3 associated with chemokine
1) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.48 Pain Relevance 0.34
After differentiation, the level of CXCR3 expression seems to be upregulated because the frequency of CXCR3hi B cells increases from naive to memory B cells.
Negative_regulation (level) of Gene_expression (expression) of CXCR3 in memory B cells
2) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.27 Pain Relevance 0.21
On the other hand, the aberrant expression of chemokines in tumors induces immunosuppression and favors tumor growth as shown in hepatocellular carcinoma, where high levels of CXCL9 and CXL10 have been associated with inhibition of CXCR3 expression by CD8+ T limphocytes, reduction of T-cell tumor infiltration and cytotoxic functions and tumor growth [48].
Negative_regulation (inhibition) of Gene_expression (expression) of CXCR3 in T-cell associated with chemokine, cancer and hepatocellular cancer
3) Confidence 0.26 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.49 Pain Relevance 0.43

General Comments

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