INT187157

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.67
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CXCR5) signal transducer activity (CXCR5)
Anatomy Link Frequency
plasma cells 1
CXCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 186 95.28 Very High Very High Very High
chemokine 246 88.96 High High
Osteoarthritis 57 75.88 Quite High
Inflammation 54 75.60 Quite High
cINOD 9 10.28 Low Low
cytokine 3 5.00 Very Low Very Low Very Low
Etanercept 3 5.00 Very Low Very Low Very Low
Adalimumab 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Infliximab 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 186 95.28 Very High Very High Very High
Systemic Lupus Erythematosus 117 95.20 Very High Very High Very High
Disease 27 79.76 Quite High
Osteoarthritis 60 75.88 Quite High
INFLAMMATION 57 75.60 Quite High
Autoimmune Disease 6 72.40 Quite High
Malignant Neoplastic Disease 6 31.20 Quite Low
Necrosis 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The downregulation of CXCR5 correlated with an upregulation of CXCR3.
Negative_regulation (downregulation) of CXCR5
1) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 1.03 Pain Relevance 0.59
The analysis of blood samples from healthy individuals showed that after activation of B cells and their differentiation into plasma cells and to some extent into memory cells, CXCR5 becomes downregulated (Fig. 3).
Negative_regulation (downregulated) of CXCR5 in plasma cells
2) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.86 Pain Relevance 0.49
In line with these results are data from an experiment in vitro in which stimulation with anti-CD40 antibodies led to a downregulation of CXCR5 [29].
Negative_regulation (downregulation) of CXCR5
3) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.77 Pain Relevance 0.45

General Comments

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