INT187168

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 11.20
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cd74) signal transduction (Cd74) Golgi apparatus (Cd74)
endoplasmic reticulum (Cd74) plasma membrane (Cd74) protein complex assembly (Cd74)
Anatomy Link Frequency
joint 3
gastric epithelium 1
dendritic cells 1
blood platelets 1
T cells 1
Cd74 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 649 99.76 Very High Very High Very High
cytokine 77 98.90 Very High Very High Very High
Inflammatory response 7 98.32 Very High Very High Very High
Inflammation 95 97.96 Very High Very High Very High
Pain 5 95.32 Very High Very High Very High
chemokine 4 94.88 High High
abatacept 1 93.28 High High
metalloproteinase 3 93.12 High High
Arthritis 131 86.76 High High
Infliximab 1 80.00 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 649 99.76 Very High Very High Very High
INFLAMMATION 106 98.32 Very High Very High Very High
Pain 5 95.32 Very High Very High Very High
Arthritis 168 94.72 High High
Lymphatic System Cancer 166 94.72 High High
Sprains And Strains 78 94.12 High High
Pneumonia 39 93.84 High High
Infection 117 91.84 High High
Disease 220 91.72 High High
Chronic Lymphoid Leukemia 28 89.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among RA patients, 13% and 33% were heterozygous for at least the HLA-DR1 and HLA-DR4 alleles, respectively.
HLA-DR4 Binding (heterozygous) of associated with rheumatoid arthritis
1) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257430 Disease Relevance 0.85 Pain Relevance 0.33
However, positivity for at least one HLA-DR1 and/or HLA-DR4 allele was found to be associated with early progression of joint damage both for the whole cohort (P = 0.011) and for the subgroup of patients with RA (P = 0.0012).


HLA-DR4 allele Binding (positivity) of in joint associated with rheumatoid arthritis
2) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257430 Disease Relevance 0.83 Pain Relevance 0.34
However, even though concomitant presence of TNFRII 196R allele and at least one HLA-DR1/DR4 allele was also found to be associated with RA diagnosis (P = 0.012), their combination did not improve upon the diagnostic accuracy of the TNFRII 196R allele alone.
HLA-DR1/DR4 Binding (associated) of associated with rheumatoid arthritis
3) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257430 Disease Relevance 0.83 Pain Relevance 0.24
Among RA patients, 13% and 33% were heterozygous for at least the HLA-DR1 and HLA-DR4 alleles, respectively.
HLA-DR1 Binding (heterozygous) of associated with rheumatoid arthritis
4) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257430 Disease Relevance 0.85 Pain Relevance 0.33
However, positivity for at least one HLA-DR1 and/or HLA-DR4 allele was found to be associated with early progression of joint damage both for the whole cohort (P = 0.011) and for the subgroup of patients with RA (P = 0.0012).


HLA-DR1 Binding (positivity) of in joint associated with rheumatoid arthritis
5) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257430 Disease Relevance 0.83 Pain Relevance 0.34
Alternatively, given that binding of H. pylori urease to CD74 on the gastric epithelium increases IL-8 secretion and up regulation of inflammatory cytokines [23] we can imagine that modification of the urease site 8 region interferes with a direct interaction with CD74-type host cell receptors, and reduces the pro-inflammatory response (which contributes to tissue damage, and thereby release of metabolites on which H. pylori is thought to feed) and thereby prevents chronic infection.
CD74-type Binding (interaction) of in gastric epithelium associated with inflammatory response, inflammation, infection and cytokine
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993952 Disease Relevance 0.43 Pain Relevance 0.21
Moreover, a role for CD4+ T cells in RA pathogenesis is inferred by the strong HLA-DR association [7].
HLA-DR Binding (association) of in T cells associated with rheumatoid arthritis
7) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.78 Pain Relevance 0.99
Quite a different explanation invokes urease-host tissue interactions, independent of enzymatic activity, and is based on in vitro studies that detected urease activation of macrophages [10], monocytes [11], blood platelets [11], dysregulation of gastric epithelial tight junctions [12] and induction of cytokine production from gastric epithelial cells [13] through binding to CD74 (MHC class II invariant chain) [14].
CD74 Binding (binding) of in blood platelets associated with cytokine
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993952 Disease Relevance 0.17 Pain Relevance 0.05
We considered HLA-DR to be a suitable activation marker for the present study, not only because of its fluorescence intensity, but also with regard to its in vivo expression (whereas e.g.
HLA-DR Binding (marker) of
9) Confidence 0.07 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.31 Pain Relevance 0
The urease of H. pylori can also bind to CD74 (the class II-associated invariant chain that regulate the intracellular transport and functions of class II) to affect the cell motility of dendritic cells [36], or cause megasome formation [37].
CD74 Binding (bind) of in dendritic cells
10) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.06 Pain Relevance 0
A role for CD4+ T cells in the pathogenesis of RA is inferred from the strong HLA-DR association as well as the large numbers of major histocompatability complex class II-positive cells found in close proximity to activated CD4+ T cells in inflamed joints.
HLA-DR Binding (association) of in joints associated with rheumatoid arthritis
11) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 1.33 Pain Relevance 0.52
IEDB, RANKPEP, SVMHC, MHCPred, and SYFPEITHI in silico analysis tools revealed peptides in PspA199–246 also interact with a broad range of HLA-DR, -DQ, and -DP allelles.
HLA-DR Binding (interact) of
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2828482 Disease Relevance 0.51 Pain Relevance 0.08
Antibodies targeting CD19, CD20, CD22, in combination with a toxin, CD23, CD40, CD80, and HLA-DR are being evaluated in clinical trials, and their additional benefit will be evaluated in coming years (DiJoseph et al 2004, 2006; Byrd et al 2005; Czuczman et al 2005; Foreno-Torres et al 2006).
HLA-DR Binding (targeting) of
13) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727901 Disease Relevance 1.22 Pain Relevance 0
Antibodies targeting CD19, CD20, CD22, in combination with a toxin, CD23, CD40, CD80, and HLA-DR are being evaluated in clinical trials, and their additional benefit will be evaluated in coming years (DiJoseph et al 2004, 2006; Byrd et al 2005; Czuczman et al 2005; Foreno-Torres et al 2006).
HLA-DR Binding (combination) of
14) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727901 Disease Relevance 1.20 Pain Relevance 0

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