INT187182

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.83
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BSG) small molecule metabolic process (BSG) plasma membrane (BSG)
Anatomy Link Frequency
plasma 1
joints 1
blood vessels 1
BSG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 99.06 Very High Very High Very High
rheumatoid arthritis 77 96.28 Very High Very High Very High
metalloproteinase 78 74.88 Quite High
antagonist 2 70.96 Quite High
spinal inflammation 16 10.08 Low Low
Gabapentin 20 5.00 Very Low Very Low Very Low
Bioavailability 12 5.00 Very Low Very Low Very Low
gABA 8 5.00 Very Low Very Low Very Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.06 Very High Very High Very High
Rheumatoid Arthritis 77 96.28 Very High Very High Very High
Cancer 44 94.28 High High
Death 13 86.40 High High
Apoptosis 5 85.96 High High
Glioma 4 83.32 Quite High
Neuroblastoma 8 82.88 Quite High
Skin Cancer 4 78.64 Quite High
Adhesions 1 76.80 Quite High
Hepatocellular Cancer 2 57.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If CyPA is released into the medium during inflammation, it is highly possible that it could act as a ligand of CD147 to induce the accumulation of inflammatory cells that highly express CD147 in the joints of RA patients.
CD147 Binding (ligand) of in joints associated with inflammation and rheumatoid arthritis
1) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.64 Pain Relevance 0.37
The initial association of CD147 and MCT1 is required for the translocation of MCT1 to the plasma membrane (48).
CD147 Binding (association) of in plasma
2) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.42 Pain Relevance 0
Topology studies suggest that one MCT1 molecule interacts with a single CD147 molecule with subsequent dimerization with another MCT1/CD147 pair.(49).
CD147 Binding (dimerization) of
3) Confidence 0.09 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.44 Pain Relevance 0
MCT1 is further regulated by its association with the cell surface glycoprotein CD147, which has a single transmembrane domain with the C-terminus located in the cytosol (48,49).
CD147 Binding (association) of
4) Confidence 0.09 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.50 Pain Relevance 0
Topology studies suggest that one MCT1 molecule interacts with a single CD147 molecule with subsequent dimerization with another MCT1/CD147 pair.(49).
CD147 Binding (dimerization) of
5) Confidence 0.09 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.44 Pain Relevance 0
3, which binds to a number of extracellular matrix proteins, is not generally expressed in normal tissues but is significantly upregulated on blood vessels undergoing angiogenesis [4].
extracellular Binding (binds) of in blood vessels
6) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1764757 Disease Relevance 0.30 Pain Relevance 0
Class I molecules consist of glycosylated heavy chains encoded by the HLA class I genes and noncovalently bound extracellular ?
extracellular Binding (bound) of
7) Confidence 0.00 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.10 Pain Relevance 0

General Comments

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