INT187183

Context Info Confidence 0.54 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 2.69 Pain Relevance 1.57

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)

Anatomy Link Frequency monocytes 2 endometrium 2 CD14 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 26 100.00 rheumatoid arthritis 180 99.76 metalloproteinase 78 99.60 Inflammation 46 97.00 Osteoarthritis 8 66.08 chemokine 31 61.24 spinal inflammation 15 54.56 endometriosis 42 5.00 dexamethasone 5 5.00 antagonist 4 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 199 99.76 INFLAMMATION 45 97.00 Glioma 22 89.12 Infection 25 83.12 Glioblastoma 27 77.04 Frailty 9 66.08 Cancer 76 60.44 Necrosis 9 55.20 Low Back Pain 15 54.56 Acquired Immune Deficiency Syndrome Or Hiv Infection 147 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the RA group, the CD14+ monocytes alone secreted more pro-MMP-9 and MMP-9 than those in the normal control group.

Localization (secreted) of CD14 in monocytes associated with metalloproteinase and rheumatoid arthritis

1) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.57 Pain Relevance 0.81

For example, endothelial cells of the blood brain barrier actively secrete cytokines to recruit CD14+ monocytes and induce migration and differentiation across the barrier in inflammatory conditions (Ifergan et al 2008).

Localization (secrete) of CD14 in monocytes associated with inflammation and cytokine

2) Confidence 0.51 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.69 Pain Relevance 0.12

CCR9 co-localised with CD14 (Figure 2a-c) and CD68 (Figure 2d-f) in RA and non-RA synovia.

Localization (localised) of CD14 associated with rheumatoid arthritis

3) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.93 Pain Relevance 0.49

In agreement with Pioli et al., who detected TLR4, CD14 and MyD88 transcripts in human endometrium [14], we were able to co-localize TLR4 with CD14 proteins suggesting the presence of both interacting receptors CD14 and TLR4 in the endometrial cells.

Localization (localize) of CD14 in endometrium

4) Confidence 0.47 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.20 Pain Relevance 0.06

In agreement with Pioli et al., who detected TLR4, CD14 and MyD88 transcripts in human endometrium [14], we were able to co-localize TLR4 with CD14 proteins suggesting the presence of both interacting receptors CD14 and TLR4 in the endometrial cells.

Localization (presence) of CD14 in endometrium

5) Confidence 0.47 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.31 Pain Relevance 0.08

The antibodies used for lineage-specific markers included CD3 (clone SP34-2), CD4 (clone L200), CD8 (clone RPA-T8), CD14 (clone M5E2), CD13 (clone L138), CD20 (clone L27), and CD34 (clone 563).

Localization (clone) of CD14

6) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0 Pain Relevance 0

General Comments

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