INT187187

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2008
Negated 0
Speculated 3
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.84
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BSG) small molecule metabolic process (BSG) plasma membrane (BSG)
Anatomy Link Frequency
monocyte 3
plasma 2
blood 2
joints 2
cartilage 2
BSG (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 380 100.00 Very High Very High Very High
metalloproteinase 390 99.44 Very High Very High Very High
antagonist 5 91.64 High High
spinal inflammation 75 78.60 Quite High
Inflammation 20 78.40 Quite High
Osteoarthritis 40 34.24 Quite Low
cINOD 5 5.00 Very Low Very Low Very Low
Gabapentin 5 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 380 100.00 Very High Very High Very High
Metastasis 1 95.96 Very High Very High Very High
Breast Cancer 1 92.60 High High
Cancer 30 90.88 High High
Necrosis 15 90.64 High High
Low Back Pain 75 78.60 Quite High
INFLAMMATION 25 78.40 Quite High
Disease 11 51.04 Quite High
Increased Venous Pressure Under Development 1 47.80 Quite Low
Frailty 45 34.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The difference between CD147 expression on monocytes in peripheral blood before and after stimulation in the control and RA groups was calculated with a LSD t-test.
Regulation (difference) of Gene_expression (expression) of CD147 in blood associated with rheumatoid arthritis
1) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.32 Pain Relevance 0.22
We conclude in this study that the increased expression of CD147 on monocytes/macrophages in RA may be responsible for elevated MMP secretion, cell invasion and the CyPA-mediated cell migration into joints, all of which may contribute to the cartilage and bone destruction of RA.
Spec (may) Regulation (responsible) of in macrophages Gene_expression (expression) of CD147 in joints associated with metalloproteinase and rheumatoid arthritis
2) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.91 Pain Relevance 0.70
Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production

Monocytes/macrophages play an important role in rheumatoid arthritis (RA) pathogenesis.

Regulation (role) of Gene_expression (Expression) of CD147 in monocyte associated with metalloproteinase and rheumatoid arthritis
3) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1257431 Disease Relevance 1.08 Pain Relevance 0.67
Our study demonstrates that the increased expression of CD147 on monocytes/macrophages in RA may be responsible for elevated MMP secretion, cell invasion and CyPA-mediated cell migration into the joints, all of which may contribute to the cartilage and bone destruction of RA.
Spec (may) Regulation (responsible) of Gene_expression (expression) of CD147 in cartilage associated with metalloproteinase and rheumatoid arthritis
4) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257431 Disease Relevance 0.38 Pain Relevance 0.50
We conclude in this study that the increased expression of CD147 on monocytes/macrophages in RA may be responsible for elevated MMP secretion, cell invasion and the CyPA-mediated cell migration into joints, all of which may contribute to the cartilage and bone destruction of RA.
Spec (may) Regulation (responsible) of in monocytes Gene_expression (expression) of CD147 in joints associated with metalloproteinase and rheumatoid arthritis
5) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.91 Pain Relevance 0.70
MCT4 localization at the plasma membrane was dependent on CD147 expression, which is consistent with results obtained for MCT1 (42).
Regulation (dependent) of Gene_expression (expression) of CD147 in plasma
6) Confidence 0.06 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.24 Pain Relevance 0

General Comments

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