INT187188

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.10
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (PPIA) isomerase activity (PPIA) protein folding (PPIA)
cytosol (PPIA) extracellular region (PPIA) nucleus (PPIA)
Anatomy Link Frequency
mononuclear cells 1
PPIA (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 48 98.54 Very High Very High Very High
rheumatoid arthritis 76 98.52 Very High Very High Very High
metalloproteinase 78 68.88 Quite High
cocaine 1 38.88 Quite Low
Calcium channel 2 31.12 Quite Low
Angina 2 25.28 Quite Low
spinal inflammation 15 5.00 Very Low Very Low Very Low
addiction 10 5.00 Very Low Very Low Very Low
Opioid 10 5.00 Very Low Very Low Very Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 14 99.74 Very High Very High Very High
Rheumatoid Arthritis 76 98.52 Very High Very High Very High
Cv General 3 Under Development 2 25.28 Quite Low
Bacillus Anthracis Infection 6 19.92 Low Low
Pressure And Volume Under Development 14 17.52 Low Low
Low Back Pain 15 5.00 Very Low Very Low Very Low
Frailty 9 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our structural analysis found that its binding site on cyclophilin A [29] overlapped completely with the complex formed by cyclophilin A and the HIV capsid [30] (Fig. 4A).
cyclophilin A Binding (binding) of associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.47 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816688 Disease Relevance 0.28 Pain Relevance 0
This overlap suggests that sanglifehrin A competes with the HIV protein for interaction with cyclophilin A.
cyclophilin A Binding (interaction) of associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.36 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816688 Disease Relevance 0.28 Pain Relevance 0
Chemoattraction of CyPA for peripheral mononuclear cells in RA and its blockage by anti-CD147 antibody and AP9
CyPA Binding (Chemoattraction) of in mononuclear cells associated with rheumatoid arthritis
3) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.53 Pain Relevance 0.45
Seven of our morphine-responsive proteins, or closely related isoforms, were also found to be modified in these studies: ATP synthase beta chain, vacuolar ATP synthase subunit B, malate dehydrogenase, triosephosphate isomerase, rab GDP dissociation inhibitor beta, peptidyl-prolyl isomerase, and septin-11.
peptidyl-prolyl isomerase Binding (modified) of associated with morphine
4) Confidence 0.04 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1766345 Disease Relevance 0 Pain Relevance 0.56

General Comments

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