INT187189

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 6.21
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BSG) small molecule metabolic process (BSG) plasma membrane (BSG)
Anatomy Link Frequency
macrophages 7
cartilage 4
blood 2
joints 2
monocytes 1
BSG (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 684 100.00 Very High Very High Very High
metalloproteinase 702 99.96 Very High Very High Very High
spinal inflammation 135 99.62 Very High Very High Very High
antagonist 9 92.04 High High
Inflammation 36 78.80 Quite High
Osteoarthritis 72 77.44 Quite High
cINOD 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 684 100.00 Very High Very High Very High
Low Back Pain 135 99.62 Very High Very High Very High
Atherosclerotic Plaque 9 98.72 Very High Very High Very High
Cancer 54 97.80 Very High Very High Very High
INFLAMMATION 45 78.80 Quite High
Frailty 81 77.44 Quite High
Necrosis 27 57.36 Quite High
Hepatocellular Cancer 18 57.36 Quite High
Disease 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the upregulation of CD147 expression on monocytes is possibly associated with the pathogenesis of RA and CD147 may play an important role in the cartilage and bone destruction of RA.
Positive_regulation (upregulation) of Gene_expression (expression) of CD147 in cartilage associated with rheumatoid arthritis
1) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.80 Pain Relevance 0.50
The upregulation of CD147 expression on monocytes/macrophages suggests that CD147 may be important in both the autocrine and paracrine stimulation of MMP expression.
Positive_regulation (upregulation) of Gene_expression (expression) of CD147 in macrophages associated with metalloproteinase
2) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.62 Pain Relevance 0.45
On the basis of this, we presume that the increased expression of CD147 on macrophages in RA synovium could possibly induce MMP production through interaction with surrounding fibroblast-like synoviocyts and also with other macrophages.
Positive_regulation (increased) of Gene_expression (expression) of CD147 in macrophages associated with metalloproteinase and rheumatoid arthritis
3) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.40 Pain Relevance 0.33
On the basis of this, we presume that the increased expression of CD147 on macrophages in RA synovium could possibly induce MMP production through interaction with surrounding fibroblast-like synoviocyts and also with other macrophages.
Positive_regulation (induce) of Gene_expression (expression) of CD147 in macrophages associated with metalloproteinase and rheumatoid arthritis
4) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.45 Pain Relevance 0.34
The expression of CD147 is upregulated in the rheumatoid arthritis synovial membrane and correlates with MMP-1, MMP-2, and MMP-3 upregulation [12,13].
Positive_regulation (upregulated) of Gene_expression (expression) of CD147 associated with metalloproteinase and rheumatoid arthritis
5) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.78 Pain Relevance 0.78
Our study demonstrates that the increased expression of CD147 on monocytes/macrophages in RA may be responsible for elevated MMP secretion, cell invasion and CyPA-mediated cell migration into the joints, all of which may contribute to the cartilage and bone destruction of RA.
Positive_regulation (increased) of Gene_expression (expression) of CD147 in cartilage associated with metalloproteinase and rheumatoid arthritis
6) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257431 Disease Relevance 0.43 Pain Relevance 0.52
We conclude in this study that the increased expression of CD147 on monocytes/macrophages in RA may be responsible for elevated MMP secretion, cell invasion and the CyPA-mediated cell migration into joints, all of which may contribute to the cartilage and bone destruction of RA.
Positive_regulation (increased) of Gene_expression (expression) of CD147 in joints associated with metalloproteinase and rheumatoid arthritis
7) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.90 Pain Relevance 0.66
In the AS group, the MFI of CD147 expression on CD14+ cells of synovial fluid (154.76 ± 27.74) was also higher than that in peripheral blood (61.77 ± 15.59, p < 0.01).


Positive_regulation (higher) of Gene_expression (expression) of CD147 in blood associated with spinal inflammation
8) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 1.23 Pain Relevance 0.98
The upregulation of CD147 expression on monocytes/macrophages suggests that CD147 may be important in both the autocrine and paracrine stimulation of MMP expression.
Positive_regulation (upregulation) of in monocytes Gene_expression (expression) of CD147 in macrophages associated with metalloproteinase
9) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.62 Pain Relevance 0.45

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