INT187190

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 30
Disease Relevance 8.10
Pain Relevance 8.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
THP-1 6
plasma 4
monocytes 4
HL-60 4
plaque 2
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 968 100.00 Very High Very High Very High
Nicotine 430 99.98 Very High Very High Very High
Inflammation 457 99.20 Very High Very High Very High
antagonist 9 96.96 Very High Very High Very High
rheumatoid arthritis 304 96.16 Very High Very High Very High
Angina 22 93.92 High High
cytokine 355 84.16 Quite High
COX2 11 82.24 Quite High
chemokine 80 79.28 Quite High
Osteoarthritis 36 76.40 Quite High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 952 99.98 Very High Very High Very High
INFLAMMATION 527 99.20 Very High Very High Very High
Atherosclerotic Plaque 37 98.32 Very High Very High Very High
Leukemia 15 98.20 Very High Very High Very High
Injury 19 97.84 Very High Very High Very High
Sarcoma 316 97.72 Very High Very High Very High
Infection 427 97.44 Very High Very High Very High
Rheumatoid Arthritis 304 96.16 Very High Very High Very High
Nicotine Addiction 295 94.36 High High
Rupture 45 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increases in AA-induced secretion of MMP-9 was blocked by co-treatment of MonoMac 6 cells with 1–10 ?
Positive_regulation (induced) of Localization (secretion) of MMP-9
1) Confidence 0.68 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
We then tested the hypothesis that AA could increase the secretion of MMP-9 by modulating its gene expression.
Positive_regulation (increase) of Localization (secretion) of MMP-9
2) Confidence 0.68 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
The secretion of MMP-9 to the medium increased in the presence of 1 ?
Positive_regulation (increased) of Localization (secretion) of MMP-9
3) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.20 Pain Relevance 0.10
In contrast, in our experiments the secretion of MMP-9 was enhanced after 1 h incubation in AA containing medium, speaking for a faster mechanism.
Positive_regulation (enhanced) of Localization (secretion) of MMP-9
4) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.08 Pain Relevance 0.12
To investigate the time course of AA-induced MMP-9 secretion we took small samples of medium at 1, 2, 4, 8, 16 and 24 h after adding 10 ?
Positive_regulation (induced) of Localization (secretion) of MMP-9
5) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
The plasma of all study participants exhibited an inhibitory effect on LPS-induced MMP-9 secretion, but interindividual variations were obvious.
Positive_regulation (induced) of Localization (secretion) of MMP-9 in plasma
6) Confidence 0.59 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0 Pain Relevance 0
The increases in AA-induced secretion of MMP-9 was blocked by co-treatment of MonoMac 6 cells with 1–10 ?
Positive_regulation (increases) of Localization (secretion) of MMP-9
7) Confidence 0.49 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
M AA with increasing concentrations of EPA, DPA or DHA for 24 h did not diminish or increase the secretion of MMP-9 (Fig. 3).
Neg (not) Positive_regulation (increase) of Localization (secretion) of MMP-9
8) Confidence 0.46 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
A concentration dependent decrease of AA-induced MMP-9 secretion was seen in zymographic analysis.
Positive_regulation (induced) of Localization (secretion) of MMP-9
9) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.08 Pain Relevance 0
Published results thus suggest that localized increase in MMP-9 associated with an inflammatory process in the vascular wall has the potential to weaken the tissue structure thus increasing the risk for plaque rupture.
Positive_regulation (increase) of Localization (localized) of MMP-9 in plaque associated with inflammation and rupture
10) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 1.16 Pain Relevance 0.46
-valerolactone exhibited inhibitory activity on LPS-induced secretion of matrix metalloproteinase 9 (MMP-9) from human monocytes [12].
Positive_regulation (induced) of Localization (secretion) of MMP-9 in monocytes associated with metalloproteinase
11) Confidence 0.43 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0.15 Pain Relevance 0.13
-valerolactone exhibited inhibitory activity on LPS-induced secretion of matrix metalloproteinase 9 (MMP-9) from human monocytes [12].
Positive_regulation (induced) of Localization (secretion) of matrix metalloproteinase 9 in monocytes associated with metalloproteinase
12) Confidence 0.43 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0.15 Pain Relevance 0.13
In the present study we show that incubation of human leukaemia Mono Mac 6 cells in the presence of AA (20:4n-6) in serum-free medium is associated with increased secretion of MMP-9 to the growth medium in comparison with control cells incubated without added AA.
Positive_regulation (increased) of Localization (secretion) of MMP-9 associated with leukemia
13) Confidence 0.40 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.10 Pain Relevance 0
Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells

Background

Positive_regulation (increases) of Localization (secretion) of matrix metalloproteinase 9 associated with metalloproteinase
14) Confidence 0.40 Published 2009 Journal Lipids Health Dis Section Title Doc Link PMC2667508 Disease Relevance 0.36 Pain Relevance 0.18
We investigated a potential influence of the plasma samples on LPS-induced release of MMP-9 from human monocytes.
Positive_regulation (induced) of Localization (release) of MMP-9 in plasma
15) Confidence 0.40 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0.17 Pain Relevance 0.08
7 nAChR in nicotine-induced MMP-9 release was determined by using the ?
Positive_regulation (induced) of Localization (release) of MMP-9 associated with nicotine and metalloproteinase
16) Confidence 0.38 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0 Pain Relevance 0.36
The nicotine-induced secretion of MMP-9 was inhibited by ?
Positive_regulation (induced) of Localization (secretion) of MMP-9 associated with nicotine
17) Confidence 0.38 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0.47 Pain Relevance 0.34
The gel zymography results show that MMP-9 and MMP-2 secretion increased significantly in the co-culture of isolated human CD14+ monocytes and fibroblasts for both the RA and normal control groups compared with the cultures of human monocytes or fibroblasts alone (Fig. 4).
Positive_regulation (increased) of Localization (secretion) of MMP-9 in fibroblasts associated with rheumatoid arthritis and metalloproteinase
18) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.68 Pain Relevance 0.89
Having established that OPN expression increases secretion of MMP-9, we next examined the functional consequences of this in an in vitro by migration assay.
Positive_regulation (increases) of Localization (secretion) of MMP-9
19) Confidence 0.35 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.27 Pain Relevance 0
The influence of nicotine on granulocytic differentiation – Inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release

Background

Positive_regulation (increased) of Localization (release) of matrix metalloproteinase-9 associated with nicotine and metalloproteinase
20) Confidence 0.29 Published 2008 Journal BMC Cell Biol Section Title Doc Link PMC2375863 Disease Relevance 0.17 Pain Relevance 0.29

General Comments

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