INT18720

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 72
Total Number 74
Disease Relevance 13.65
Pain Relevance 13.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
choroid plexus 7
cerebrospinal fluid 6
brain 3
juvenile 3
spinal 2
Csf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 102 100.00 Very High Very High Very High
Inflammation 70 100.00 Very High Very High Very High
cytokine 66 100.00 Very High Very High Very High
excitatory amino acid 7 100.00 Very High Very High Very High
Analgesic 6 100.00 Very High Very High Very High
Morphine 54 99.84 Very High Very High Very High
qutenza 18 99.66 Very High Very High Very High
Endep 11 99.52 Very High Very High Very High
Hyperalgesia 9 99.40 Very High Very High Very High
intrathecal 103 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 77 100.00 Very High Very High Very High
Brain Injury 11 99.92 Very High Very High Very High
Hyperalgesia 11 99.40 Very High Very High Very High
Pain 32 99.28 Very High Very High Very High
Stress 29 99.08 Very High Very High Very High
Hydrocephalus 122 99.04 Very High Very High Very High
Frailty 11 98.68 Very High Very High Very High
Cancer 23 98.52 Very High Very High Very High
Urological Neuroanatomy 11 98.52 Very High Very High Very High
Arachnoid Cysts 88 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antibiotic differences have also implications for the possible clinical use of G-CSF.
Spec (possible) Localization (use) of G-CSF
1) Confidence 0.67 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2386131 Disease Relevance 0.49 Pain Relevance 0.27
The effects of the continuous thoracic blockade on tail-flick (TF) latency (estimated by the percent maximum possible effect [%MPE]) and on the release of neurotransmitters in the cerebrospinal fluid (CSF) were evaluated.
Localization (release) of CSF in cerebrospinal fluid
2) Confidence 0.66 Published 2009 Journal J Anesth Section Body Doc Link 19685121 Disease Relevance 0 Pain Relevance 0
Serial plasma and CSF samples were collected for 6 h, and the drug concentrations were assayed by an HPLC-fluorescence method.
Localization (samples) of CSF in CSF
3) Confidence 0.64 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18718117 Disease Relevance 0 Pain Relevance 0.48
However, it is possible that the impediment to lymphatic CSF transport may be a local phenomenon with CSF clearance increasing at other absorption sites to compensate, such that global CSF absorption is relatively unchanged.
Localization (transport) of CSF
4) Confidence 0.61 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.40 Pain Relevance 0.11
Transport of CSF tracer into olfactory turbinates: comparison between kaolin and saline injected animals
Localization (Transport) of CSF in olfactory
5) Confidence 0.61 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.15 Pain Relevance 0
No significant differences were observed in CSF amino acid release between the groups from day 1 to day 5.
Localization (release) of CSF
6) Confidence 0.59 Published 2004 Journal Brain Res. Section Abstract Doc Link 14672815 Disease Relevance 0 Pain Relevance 1.79
OBJECTIVE: Stress- and pain-related stimuli cause a release of vasopressin (AVP) and oxytocin (OT) into the cerebrospinal fluid (CSF) and extracellular fluid of the brain in various animal species.
Localization (release) of CSF in cerebrospinal fluid associated with stress and pain
7) Confidence 0.59 Published 2007 Journal Endocr Regul Section Abstract Doc Link 18257651 Disease Relevance 0.20 Pain Relevance 0.18
The tissue profiles showed some penetration of IGF-1 into the brain immediately adjacent to the CSF (Fig. 9A, caudate-putamen; Fig. 9B, periaqueductal gray matter) over the first 9 min when blood-contained radioactivity was low (Fig. 3).
Localization (penetration) of CSF in gray matter associated with central grey
8) Confidence 0.53 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.18 Pain Relevance 0.09
Moreover, that intra-CSF injected DCs enhanced the systemic antibody response further demonstrates that DCs are able to migrate from the CSF to the CLNs.
Localization (migrate) of CSF
9) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2552991 Disease Relevance 0.42 Pain Relevance 0.18
As proteins are mainly cleared from CSF by lumbar drainage, neurotrophins released into the CSF of children with acute hydrocephalus will be retained as long as the impaired drainage persists.
Localization (released) of CSF associated with hydrocephalus
10) Confidence 0.53 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.54 Pain Relevance 0.73
Functional significance of the existence of CSF-soluble proteins secreted by the SCO
Localization (secreted) of CSF
11) Confidence 0.52 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0
METHODS: Rats were treated with several doses of indomethacin alone or in association with substances known to increase (interleukin 2 and lipopolysaccharide) or inhibit (pentoxifylline, dexamethasone, granulocyte colony-stimulating factor [G-CSF]) TNF synthesis and release.
Localization (release) of G-CSF in granulocyte
12) Confidence 0.51 Published 1995 Journal Gastroenterology Section Body Doc Link 7530670 Disease Relevance 0 Pain Relevance 0
We have recently described the up-regulation of the CSF-secreting cation chloride co-transporter NKCC1 in AC membranes compared with normal arachnoid [8].
Localization (secreting) of CSF associated with arachnoid cysts
13) Confidence 0.51 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2898803 Disease Relevance 1.30 Pain Relevance 0
We have recently described the up-regulation of the CSF-secreting cation chloride co-transporter NKCC1 in AC membranes compared with normal arachnoid [8].
Localization (-) of CSF associated with arachnoid cysts
14) Confidence 0.51 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2898803 Disease Relevance 1.30 Pain Relevance 0
However, optimal activation and mobilization of neutrophils into the cerebrospinal fluid (CSF) and improved penetration of MAb to tumor sites remain critical variables.
Localization (mobilization) of CSF in neutrophils associated with cancer
15) Confidence 0.51 Published 1999 Journal Int. J. Cancer Section Abstract Doc Link 10404068 Disease Relevance 0.73 Pain Relevance 0
In other cases, CSF-derived DCs were clearly localized within parenchymal inflammatory foci.
Localization (localized) of CSF associated with inflammation
16) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2552991 Disease Relevance 0.20 Pain Relevance 0.13
The two proteins of 180 and 164 kDa, found in the embryonic CSF but absent from the juvenile SCO, CSF and RF, would correspond to processed forms released by the SCO during late embryonic life.
Localization (released) of embryonic CSF in juvenile
17) Confidence 0.48 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.04
The results demonstrated that MO-induced hyperalgesia is associated with increased CSF-Glu release and that this effect is potentiated by a NGF inducer.
Localization (release) of CSF-Glu associated with hyperalgesia and nerve growth factor
18) Confidence 0.46 Published 1999 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 10384257 Disease Relevance 0.10 Pain Relevance 0.73
The present investigation has shown that (i) during late embryonic life, the SCO secretes compounds that remain soluble in the CSF and reach the subarachnoid space; (ii) during postnatal life, there is a reduction in the number and concentration of CSF-soluble proteins secreted by the SCO.
Localization (secreted) of CSF
19) Confidence 0.45 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0.08 Pain Relevance 0
Are CSF-soluble compounds secreted by the SCO intracellularly processed and released into CSF, or "released" from RF?
Localization (secreted) of CSF
20) Confidence 0.45 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0

General Comments

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