INT187219

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip, Ccl3) cytosol (Ccl3) extracellular space (Ccl3)
intracellular (Ccl3) cytoskeleton organization (Ccl3) kinase activity (Ccl3)
Anatomy Link Frequency
monocyte 2
Vip (Mus musculus)
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 3 100.00 Very High Very High Very High
Arthritis 54 91.44 High High
rheumatoid arthritis 33 64.00 Quite High
cytokine 36 54.92 Quite High
Inflammation 24 54.20 Quite High
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Freund adjuvant 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 64 93.24 High High
Rheumatoid Arthritis 33 64.00 Quite High
Hypercalcemia 11 63.64 Quite High
INFLAMMATION 28 54.20 Quite High
Immunization 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low
Osteoporosis 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Autoimmune Disease 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect may be due to the inhibition of RANK synthesis or, alternatively, to the inhibition of monocyte recruitment; we have reported previously that VIP inhibits the local expression of the monocyte chemoatractant chemokines CCL3 (MIP1?)
VIP Negative_regulation (inhibits) of Gene_expression (expression) of CCL3 in monocyte associated with chemokine
1) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.65 Pain Relevance 0.35

General Comments

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