INT187222

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.82
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Vipr2) extracellular region (Vip) plasma membrane (Vipr2)
signal transducer activity (Vipr2)
Anatomy Link Frequency
blood 1
pituitary 1
Vip (Mus musculus)
Vipr2 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 33 87.60 High High
Inflammation 139 85.28 High High
antagonist 3 79.08 Quite High
Peripheral nervous system 1 75.20 Quite High
cytokine 45 72.32 Quite High
substance P 17 69.28 Quite High
Arthritis 54 50.00 Quite Low
Crohn's disease 25 31.76 Quite Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 96 89.16 High High
Rheumatoid Arthritis 33 87.60 High High
Autoimmune Disease 3 86.28 High High
INFLAMMATION 140 85.28 High High
Colitis 60 73.12 Quite High
Ileitis 3 67.84 Quite High
Clostridium Difficile Infection 2 67.52 Quite High
Hypercalcemia 11 64.48 Quite High
Severe Combined Immunodeficiency 1 60.28 Quite High
Arthritis 64 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biological effects of VIP are mediated by G protein-coupled receptors (VPAC1 and VPAC2) that bind VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) with equal affinity, and a PACAP selective receptor (PAC1) [25].
VIP Binding (bind) of VPAC2 in pituitary
1) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.40 Pain Relevance 0.19
Functionally, VIP inhibits the peristaltic reflex in the circular muscle layer, controls intestinal blood flow, and modulates the immune system by binding to two G-protein-coupled VIP receptor -- VPAC1 and VPAC2 -- which are also shared by PACAP.
VIP Binding (binding) of VPAC2 in blood
2) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.41 Pain Relevance 0.37

General Comments

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