INT187225

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.92
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
joints 4
bone marrow 2
Vip (Mus musculus)
Tnfrsf11a (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 99 99.72 Very High Very High Very High
Arthritis 162 99.28 Very High Very High Very High
chemokine 9 97.84 Very High Very High Very High
cytokine 108 65.64 Quite High
Inflammation 72 64.92 Quite High
Inflammatory mediators 12 5.00 Very Low Very Low Very Low
Freund adjuvant 6 5.00 Very Low Very Low Very Low
Peripheral nervous system 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 99 99.72 Very High Very High Very High
Arthritis 192 99.28 Very High Very High Very High
Hypercalcemia 33 74.36 Quite High
INFLAMMATION 84 64.92 Quite High
Immunization 18 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 15 5.00 Very Low Very Low Very Low
Osteoporosis 12 5.00 Very Low Very Low Very Low
Necrosis 9 5.00 Very Low Very Low Very Low
Autoimmune Disease 9 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VIP has been reported to inhibit the expression of RANKL and RANK induced by vitamin D in mouse bone marrow cultures [28].
VIP Negative_regulation (inhibit) of Gene_expression (expression) of RANK in bone marrow
1) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.62 Pain Relevance 0.27
We also describe how VIP lowers the expression of RANK in the joints of CIA mice to the levels detected in non-arthritic control mice.
VIP Negative_regulation (lowers) of Gene_expression (expression) of RANK in joints associated with arthritis
2) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.70 Pain Relevance 0.37
Results shown in this report indicate that VIP reduces the expression of RANK and RANKL in the joints of arthritic mice, and may account for the bone protective properties of VIP in RA.
VIP Negative_regulation (reduces) of Gene_expression (expression) of RANK in joints associated with rheumatoid arthritis and arthritis
3) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.61 Pain Relevance 0.23

General Comments

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