INT187227

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip, Tnfsf11) cell differentiation (Tnfsf11) extracellular space (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
joints 2
bone marrow 2
Vip (Mus musculus)
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 66 99.72 Very High Very High Very High
Arthritis 108 87.40 High High
chemokine 6 71.00 Quite High
Inflammation 48 42.56 Quite Low
cytokine 72 22.92 Low Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
Freund adjuvant 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 66 99.72 Very High Very High Very High
Arthritis 128 99.28 Very High Very High Very High
Hypercalcemia 22 55.28 Quite High
INFLAMMATION 56 42.56 Quite Low
Immunization 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 10 5.00 Very Low Very Low Very Low
Osteoporosis 8 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Autoimmune Disease 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results shown in this report indicate that VIP reduces the expression of RANK and RANKL in the joints of arthritic mice, and may account for the bone protective properties of VIP in RA.
VIP Negative_regulation (reduces) of Gene_expression (expression) of RANKL in joints associated with rheumatoid arthritis and arthritis
1) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.61 Pain Relevance 0.23
VIP has been reported to inhibit the expression of RANKL and RANK induced by vitamin D in mouse bone marrow cultures [28].
VIP Negative_regulation (inhibit) of Gene_expression (expression) of RANKL in bone marrow
2) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.61 Pain Relevance 0.27

General Comments

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