INT187228

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adcyap1, Vipr2) extracellular space (Adcyap1) extracellular region (Adcyap1)
plasma membrane (Vipr2) signal transducer activity (Vipr2)
Anatomy Link Frequency
pituitary 2
Adcyap1 (Mus musculus)
Vipr2 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 66 87.60 High High
Inflammation 48 85.28 High High
Peripheral nervous system 2 75.20 Quite High
cytokine 72 52.72 Quite High
Arthritis 108 50.00 Quite Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Freund adjuvant 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 66 87.60 High High
Autoimmune Disease 6 86.28 High High
INFLAMMATION 56 85.28 High High
Hypercalcemia 22 64.48 Quite High
Arthritis 128 50.00 Quite Low
Osteoporosis 8 36.52 Quite Low
Necrosis 6 22.80 Low Low
Cancer 6 22.44 Low Low
Immunization 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biological effects of VIP are mediated by G protein-coupled receptors (VPAC1 and VPAC2) that bind VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) with equal affinity, and a PACAP selective receptor (PAC1) [25].
PACAP Binding (bind) of VPAC2 in pituitary
1) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.46 Pain Relevance 0.19
The biological effects of VIP are mediated by G protein-coupled receptors (VPAC1 and VPAC2) that bind VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) with equal affinity, and a PACAP selective receptor (PAC1) [25].
cyclase-activating polypeptide Binding (bind) of VPAC2 in pituitary
2) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.46 Pain Relevance 0.19

General Comments

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