INT187231

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
precursor cells 2
Tnfrsf11a (Mus musculus)
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 66 92.04 High High
cytokine 72 89.36 High High
Peripheral nervous system 2 89.20 High High
Inflammation 48 76.08 Quite High
Arthritis 108 71.28 Quite High
chemokine 6 50.76 Quite High
Freund adjuvant 4 39.84 Quite Low
Pain 2 36.48 Quite Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 22 100.00 Very High Very High Very High
Rheumatoid Arthritis 66 92.04 High High
Arthritis 128 89.24 High High
INFLAMMATION 56 76.08 Quite High
Osteoporosis 8 73.16 Quite High
Autoimmune Disease 6 66.64 Quite High
Necrosis 6 59.44 Quite High
Cancer 6 59.08 Quite High
Immunization 12 37.28 Quite Low
Arthralgia 2 36.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This molecule is secreted by stromal cells and osteoblasts and competitively inhibits RANKL binding to RANK on the cell surface of osteoclast precursor cells and mature osteoclasts, thus inhibiting the osteoclastogenic actions of RANKL.
Negative_regulation (inhibits) of RANK Binding (binding) of RANKL in precursor cells
1) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.75 Pain Relevance 0.32
OPG inhibits bone resorption and binds with strong affinity to its ligand, RANKL, thereby preventing RANKL binding to its receptor, RANK [11,13,14].
Negative_regulation (preventing) of RANK Binding (binding) of OPG associated with hypercalcemia
2) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 1.05 Pain Relevance 0.40

General Comments

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