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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.32
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam17) extracellular region (Adam17) cell motility (Adam17)
cell adhesion (Adam17) plasma membrane (Adam17) cytoplasm (Adam17)
Adam17 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 10 92.56 High High
Inflammation 43 76.64 Quite High
cytokine 39 72.24 Quite High
fibrosis 9 66.28 Quite High
rheumatoid arthritis 142 50.00 Quite Low
metalloproteinase 48 50.00 Quite Low
Multiple sclerosis 19 5.00 Very Low Very Low Very Low
Etanercept 15 5.00 Very Low Very Low Very Low
Infliximab 10 5.00 Very Low Very Low Very Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dilated Cardiomyopathy 3 95.20 Very High Very High Very High
Cv General 4 Under Development 192 92.56 High High
Hypertrophy 8 91.24 High High
Targeted Disruption 37 86.64 High High
Glioblastoma 1 85.60 High High
INFLAMMATION 47 76.64 Quite High
Necrosis 7 72.84 Quite High
Cancer 6 72.48 Quite High
Fibrosis 8 66.28 Quite High
Rheumatoid Arthritis 144 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, Hiraoka et al. [74] demonstrated that overexpression of ADAM17 in COS7 cells lead to a significant increase in basal sAPP?
Positive_regulation (overexpression) of Gene_expression (overexpression) of ADAM17
1) Confidence 0.20 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.15 Pain Relevance 0
The balance between tmTNF and solTNF signaling is influenced by cell type, activation status of the cell, the stimulus eliciting TNF production, TACE activity, and expression of endogenous TACE inhibitors leading to divergent TNF-mediated effects on cellular viability [10,11].
Positive_regulation (eliciting) of Gene_expression (expression) of TACE
2) Confidence 0.16 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.29 Pain Relevance 0.20
In humans, increased TACE expression parallels the increase in TNF-?
Positive_regulation (increased) of Gene_expression (expression) of TACE
3) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 0.87 Pain Relevance 0.09

General Comments

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