INT1873

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Context Info
Confidence 0.76
First Reported 1976
Last Reported 2010
Negated 12
Speculated 2
Reported most in Abstract
Documents 51
Total Number 55
Disease Relevance 31.75
Pain Relevance 13.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (MRAP) plasma membrane (MRAP) cytoplasm (MRAP)
Anatomy Link Frequency
leukocyte 4
KG-1 3
lateral spine 1
axial skeleton 1
anterior 1
MRAP (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 225 100.00 Very High Very High Very High
psoriasis 8 100.00 Very High Very High Very High
Rheumatism 1 100.00 Very High Very High Very High
Inflammation 21 99.98 Very High Very High Very High
backache 8 99.84 Very High Very High Very High
rheumatoid arthritis 15 99.80 Very High Very High Very High
Arthritis 32 99.52 Very High Very High Very High
corticosteroid 1 98.16 Very High Very High Very High
Pain 5 96.92 Very High Very High Very High
cINOD 1 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Low Back Pain 199 100.00 Very High Very High Very High
Seronegative Spondarthritis 76 100.00 Very High Very High Very High
Syndrome 30 100.00 Very High Very High Very High
Rheumatic Diseases 9 100.00 Very High Very High Very High
Psoriasis 8 100.00 Very High Very High Very High
INFLAMMATION 12 99.98 Very High Very High Very High
Rheumatoid Arthritis 15 99.80 Very High Very High Very High
Arthritis 24 99.52 Very High Very High Very High
Alzheimer's Dementia 1 99.22 Very High Very High Very High
Uveitis 15 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The histocompatibility antigen, HL-A B27, was not present in these patients.
Neg (not) Gene_expression (present) of B27
1) Confidence 0.76 Published 1977 Journal J. Rheumatol. Section Abstract Doc Link 881689 Disease Relevance 0.53 Pain Relevance 0.13
Human leukocyte antigen (HLA) B27, which has been characteristic of ankylosing spondylitis, was also present in this case.
Gene_expression (present) of B27 in leukocyte associated with spinal inflammation
2) Confidence 0.75 Published 2001 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 11855083 Disease Relevance 1.29 Pain Relevance 0.32
Laboratory findings showed positive tests of inflammatory activity, while the rheumatoid factors and the HLA B 27 antigen were negative.
Neg (negative) Gene_expression (negative) of B 27 associated with inflammation
3) Confidence 0.75 Published 1984 Journal Z Rheumatol Section Abstract Doc Link 6332438 Disease Relevance 0.92 Pain Relevance 0.14
Rheumatoid factor and human leukocyte antigen B-27 were negative.
Neg (negative) Gene_expression (negative) of B-27 in leukocyte
4) Confidence 0.75 Published 2009 Journal Mod Rheumatol Section Abstract Doc Link 19083078 Disease Relevance 0.98 Pain Relevance 0.45
Only two patients had the B27 antigen: both patients had uveitis, but eight others who also had uveitis were B27 negative.
Gene_expression (had) of B27 associated with uveitis
5) Confidence 0.66 Published 1976 Journal J. Rheumatol. Section Abstract Doc Link 1271386 Disease Relevance 0.86 Pain Relevance 0.27
A positive family history was elicited in two patients (13%) and HLA B27 was positive in eight out of twelve patients (67%).
Gene_expression (positive) of B27 associated with seronegative spondarthritis
6) Confidence 0.66 Published 1996 Journal Clin. Rheumatol. Section Abstract Doc Link 8793262 Disease Relevance 0.51 Pain Relevance 0.21
[Chronic inflammatory rheumatism in children and the HLA B27 antigen].
Gene_expression (rheumatism) of B27 associated with seronegative spondarthritis, inflammation and rheumatism
7) Confidence 0.65 Published 1983 Journal Pediatrie Section Title Doc Link 6608095 Disease Relevance 0.48 Pain Relevance 0.24
Patients with sacro-iliitis did not possess the HLA B27 antigen.
Neg (not) Gene_expression (possess) of B27 associated with seronegative spondarthritis
8) Confidence 0.65 Published 1983 Journal Br J Radiol Section Abstract Doc Link 6824840 Disease Relevance 0.97 Pain Relevance 0.17
This was the case also when HLA B27 positives and patients who did not have psoriasis were considered separately.
Gene_expression (positives) of B27 associated with seronegative spondarthritis and psoriasis
9) Confidence 0.65 Published 1982 Journal Clin. Genet. Section Abstract Doc Link 6983935 Disease Relevance 1.56 Pain Relevance 0.49
When these new findings are added to the previous observations that acute anterior uveitis probably is a clinical, sex-influenced characteristic of HLA B27 positive Bechterew's syndrome, that HLA B27 negative patients with Bechterew's syndrome frequently had psoriasis and were HLA B13 and B17 negative, and that psoriasis was frequent in HLA B27 positive patients as well, we tentatively conclude that different and interacting genetic mechanisms may be involved in the etiology of Bechterew's syndrome.
Gene_expression (negative) of B27 in anterior associated with seronegative spondarthritis, psoriasis, syndrome and uveitis
10) Confidence 0.65 Published 1982 Journal Clin. Genet. Section Abstract Doc Link 6983935 Disease Relevance 2.28 Pain Relevance 0.51
Significant distinguishing characteristics of the group included male predominance, late age at onset, positive family histories of arthritis, oligoarthropathy, axial skeleton involvement, and the presence of the B27 histocompatibility antigen.
Gene_expression (presence) of B27 in axial skeleton associated with arthritis
11) Confidence 0.65 Published 1982 Journal Arthritis Rheum. Section Abstract Doc Link 7126288 Disease Relevance 1.21 Pain Relevance 0.27
Serological tests including rheumatoid factor, antinuclear antibody, and human leukocyte antigen B27 were all negative.
Neg (negative) Gene_expression (negative) of B27 in leukocyte
12) Confidence 0.65 Published 2004 Journal Rheumatol. Int. Section Abstract Doc Link 14593491 Disease Relevance 0.72 Pain Relevance 0.15
Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: implications for disease pathogenesis.
Gene_expression (harbor) of B27 associated with spinal inflammation and disease
13) Confidence 0.65 Published 2003 Journal Arthritis Rheum. Section Title Doc Link 12746911 Disease Relevance 0.19 Pain Relevance 0.46
The distribution of B27 alleles was characterised in six different Asian populations.
Gene_expression (distribution) of B27
14) Confidence 0.65 Published 2001 Journal Tissue Antigens Section Abstract Doc Link 11782278 Disease Relevance 0.13 Pain Relevance 0.13
Is HLA-B27 the ankylosing spondylitis susceptibility gene?
Gene_expression (ankylosing) of B27 associated with spinal inflammation
15) Confidence 0.65 Published 1985 Journal J. Rheumatol. Section Title Doc Link 3878882 Disease Relevance 0.62 Pain Relevance 0.49
RA patients possessing the B27 antigen did not differ regarding the age of the onset of disease, the distribution of affected joints during the follow-up (3-10 years), the development stages of the disease and the presence of rheumatoid factor when compared with B27 negative RA patients.
Gene_expression (possessing) of B27 in joints associated with rheumatoid arthritis and disease
16) Confidence 0.65 Published 1991 Journal Acta Med Iugosl Section Abstract Doc Link 1950638 Disease Relevance 0.86 Pain Relevance 0.33
Speculative factors which may predispose to apical fibrobullous disease, such as a stiff chest wall, impaired esophageal motiligy, and HL-A antigen B27, were not present in our patient.
Neg (not) Gene_expression (present) of B27 in chest associated with disease
17) Confidence 0.65 Published 1979 Journal Chest Section Abstract Doc Link 436534 Disease Relevance 0.69 Pain Relevance 0.22
The rheumatologic consultation included recordal of clinical history and family history; physical examination, including a Schober's test, lateral spine flexion, chest expansion, cervical rotation, and tragus-to-wall distance; blood tests, including genotyping for human leukocyte antigen B27 positivity, and measurements of C-reactive protein level and erythrocyte sedimentation rate; MRI of the sacroiliac joints with use of short tau inversion recovery sequences; and measurement of the Bath Ankylosing Spondylitis Disease Activity Index and the Bath Ankylosing Spondylitis Functional Index.
Gene_expression (positivity) of B27 in lateral spine
18) Confidence 0.65 Published 2007 Journal Nature clinical practice. Rheumatology Section Body Doc Link 17471249 Disease Relevance 0.08 Pain Relevance 0
HLA B 27 antigen was present in 8 of the 9 patients tested.
Gene_expression (present) of B 27
19) Confidence 0.65 Published 1977 Journal Radiology Section Abstract Doc Link 928708 Disease Relevance 0.61 Pain Relevance 0.47
Levels were higher in HLA B-27 negative patients (p = 0.02).
Neg (negative) Gene_expression (negative) of B-27
20) Confidence 0.65 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.53 Pain Relevance 0.28

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